The contraceptive efficacy of intravas injection of Vasalgel™ for adult male rhesus monkeys

Basic and Clinical Andrology

Research Article

Angela Colagross-Schouten¹  Rebekah I. Keesler¹  Marie-Josee Lemoy¹  Catherine A. VandeVoort²  Elaine Lissner³ 

[1] California National Primate Research, University of California, One Shields Ave, 95616, Davis, CA, USA;California National Primate Research, University of California, One Shields Ave, 95616, Davis, CA, USA;Department of Obstetrics and Gynecology, University of California, 95616, Davis, CA, USA;Parsemus Foundation, PO Box 2246, 94702, Berkeley, CA, USA;

关键词: Primate;    Macaca mulatta;    Hydrogel;    Vas deferens;    Styrene maleic acid polymer;    Fertility;    Vasectomy;    Vasalgel;    Contraception;    Sterilization;    Colony management;    Primate;    Macaca mulatta;    Hydrogel;    Canal déférent;    Polymère d’acide styrène-alt-maléique;    Fécondité;    Vasectomie;    Vasalgel™;    Contraception;    Stérilisation;    Gestion de colonie;   

DOI  :  10.1186/s12610-017-0048-9

 received in 2016-08-04, accepted in 2017-01-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundOptions for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men.MethodsSixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history.ResultsTreated males have had no conceptions since Vasalgel injections. All males were housed with intact females for at least one breeding season and seven have been almost continually housed with females for 2 years. Complications were minor and included one incident of incorrect placement of Vasalgel into the vas deferens and the development of a sperm granuloma in one animal. Three unilateral vasectomies were performed, one was necessary for incorrect placement of Vasalgel, the other two were elective.ConclusionsIntravas injection of Vasalgel in sexually mature adult male rhesus monkeys was effective in preventing conception in a free-living, group environment. Complications were few and similar to those associated with traditional vasectomy.

【 授权许可】

CC BY   
© The Author(s). 2017