Azoospermia in rabbits following an intravas injection of Vasalgel ™

Basic and Clinical Andrology

Research Article

Christopher Premanandan¹  Elaine Lissner²  Donald Waller³  David Bolick⁴  Gary Gamerman⁴ 

[1] Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, 43215, Columbus, OH, USA;Parsemus Foundation, PO Box 2246, 94702, Berkeley, CA, USA;Prelabs, LLC Inc., 33 W Chicago Ave., 60302, Oak Park, IL, USA;Seraphim Life Sciences Consulting, LLC, 2158 Bonaventure Drive, Suite 101, 22181, Vienna, VA, USA;

关键词: Male contraception;    Hydrogel;    Vas deferens;    Styrene maleic acid;    Polymer;    Vasectomy;   

DOI  :  10.1186/s12610-016-0033-8

 received in 2015-09-29, accepted in 2016-03-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundVasectomy is currently the only long-acting contraceptive option available for men, despite increasing demand and potentially significant positive impacts on human health of additional male contraceptive options. Vasalgel ™ is a high molecular weight hydrogel polymer being developed as a non-hormonal long-acting reversible male contraceptive. Vasalgel consists of styrene-alt-maleic acid dissolved in dimethyl sulfoxide, which is distinct from styrene-alt-maleic anhydride materials previously studied.MethodsThe goal of the study was to determine the contraceptive efficacy of two test articles with different levels of styrene maleic acid (100 %, and 80 % acid/20 % anhydride). The test articles were injected bilaterally in the vasa deferentia of mature male rabbits. Post-implantation analyses of semen parameters were completed over a 12 month period and compared to baseline measures of sperm concentration, motility and forward progression.ResultsBoth test articles were effective in blocking the passage of spermatozoa through the vasa deferentia in the 12 subjects completing the study. A significant decrease in sperm concentration occurred following implantation of the test material, with no measurable sperm concentration except for a few samples in one animal that were markedly oligospermic. Vasalgel produced a rapid onset of azoospermia, with no sperm in semen samples collected as early as 29–36 days post-implantation, and was durable over a 12 month period.ConclusionThis study indicated that Vasalgel is an effective non-hormonal long-acting male contraceptive in a rabbit model.

【 授权许可】

CC BY   
© Waller et al. 2016