White matter damage and systemic inflammation in Parkinson’s disease

BMC Neuroscience

Research Article

Pi-Ling Chiang¹  I.-Hsiao Yang¹  Pei-Chin Chen¹  Hsiu-Ling Chen¹  Wei-Che Lin¹  Meng-Hsiang Chen¹  Nai-Wen Tsai²  Cheng-Hsien Lu³ 

[1] Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, 83305, Kaohsiung, Taiwan;Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan;Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan;Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, Taiwan;

关键词: Systemic inflammation;    White matter damage;    Diffusion tensor imaging;    Parkinson’s disease;   

DOI  :  10.1186/s12868-017-0367-y

 received in 2016-11-26, accepted in 2017-05-31,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSystemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) and to assess its relationship with systemic inflammation.MethodsSixty-six patients with PD (23 men and 43 women) and 67 healthy volunteers (29 men and 38 women) underwent blood sampling to quantify inflammatory markers and DTI scans to determine fiber integrity. The inflammatory markers included leukocyte apoptosis, as well as cellular and serum adhesion molecules, in each peripheral blood sample. DTI-related indices [including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] were derived from DTI scans. The resulting FA maps were compared using voxel-based statistics to determine differences between the PD and control groups. The differences in the DTI indices, clinical severity, and inflammatory markers were correlated.ResultsExploratory group-wise comparison between the two groups revealed that the PD patients exhibited extensive DTI index differences. Low FA accompanied by high RD and MD, without significant differences in AD, suggesting a demyelination process, were found in the parietal, occipital, cerebellar, and insular WM of the PD patients. The declined DTI indices were significantly correlated with increased clinical disease severity, adhesion molecules, and leukocyte apoptosis.ConclusionsPatients with PD experience WM integrity damage in vulnerable regions, and these impairments are associated with increased disease severity and systemic inflammation. The possible interactions among them may represent variant neuronal injuries and their consequent processes in PD.

【 授权许可】

CC BY   
© The Author(s) 2017