Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities

Fluids and Barriers of the CNS

Kazuhisa Domen³  Hiroji Miyake¹  Norihiko Kodama³  Masashi Hosomi³  Tetsuo Koyama²  Kohei Marumoto³ 

[1] Department of Neurosurgery, Nishinomiya Kyoritsu Neurosurgical Hospital, 11-1 Imazu-Yamanaka-cho, Nishinomiya, Hyogo 663-8211, Japan;Department of Rehabilitation Medicine, Nishinomiya Kyoritsu Neurosurgical Hospital, 11-1 Imazu-Yamanaka-cho, Nishinomiya, Hyogo 663-8211, Japan;Department of Physical Medicine and Rehabilitation, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan

关键词: White matter;    Parkinson’s disease;    Idiopathic normal pressure hydrocephalus;    Fractional anisotropy;    Diffusion tensor imaging;   

Others  :  807146
DOI  :  10.1186/2045-8118-9-20

 received in 2012-06-14, accepted in 2012-08-20,  发布年份 2012

【 摘 要 】

Background

Gait abnormalities in the elderly, characterized by short steps and frozen gait, can be caused by several diseases, including idiopathic normal pressure hydrocephalus (INPH), and Parkinson’s disease (PD). We analyzed the relationship between these two conditions and their association with gait abnormalities using laboratory test data and findings from diffusion tensor imaging (DTI).

Methods

The study involved 10 patients with INPH, 18 with PD, and 10 healthy individuals (control group). Fractional anisotropy (FA) of five brain areas was measured and compared among the three groups. In addition, the association of INPH and PD with gait capability, frontal lobe function, and FA of each brain area was evaluated.

Results

The INPH group had significantly lower FA for anterior thalamic radiation (ATR) and forceps minor (Fmin) as compared to the PD group. The gait capability correlated with ATR FA in the INPH and PD groups. We found that adding DTI to the diagnosis assisted the differential diagnosis of INPH from PD, beyond what could be inferred from ventricular size alone.

Conclusions

We expect that DTI will provide a useful tool to support the differential diagnosis of INPH and PD and their respective severities.

【 授权许可】

   
2012 Marumoto et al.; licensee BioMed Central Ltd.

【 图 表 】

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