Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells

BMC Complementary and Alternative Medicine

Research Article

Noor Hayaty Abu Kasim¹  Nazmul Haque¹  Noor Lide Abu Kassim²  Mohammad Tariqur Rahman³  Jazli Aziz³ 

[1] Department of Restorative Dentistry, Faculty of Dentistry, University Malaya, 50603, Kuala Lumpur, Malaysia;Faculty of Dentistry, International Islamic University Malaysia, Bandar Indera Mahkota, 25200, Kuantan, Malaysia;Faculty of Science, International Islamic University Malaysia, Bandar Indera Mahkota, 25200, Kuantan, Malaysia;

关键词: Dengue fever;    Megakaryopoiesis;    Thrombocytes;    Interleukin-6;    Stem cell Factor;   

DOI  :  10.1186/s12906-015-0749-6

 received in 2015-01-17, accepted in 2015-06-25,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundUse of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines inductionMethodsIn vitro cultures of peripheral blood leukocytes (PBL) and stem cells from human exfoliated deciduous teeth (SHED) were treated with unripe papaya pulp juice (UPJ) to evaluate its potential to induce thrombopoietic cytokines (IL-6 and SCF)ResultsIn vitro scratch gap closure was significantly faster (p < .05) in SHED culture treated with UPJ. IL-6 concentration was significantly increased (p < .05) in SHED and PBL culture supernatant when treated with UPJ. SCF synthesis in SHED culture was also significantly increased (p < .05) when treated with UPJConclusionIn vitro upregulated synthesis of IL −6 and SCF both in PBL and SHED reveals the potential mechanism of unripe papaya to induce thrombopoietic cytokines synthesis in cells of hematopoietic and mesenchymal origin.

【 授权许可】

Unknown   
© Aziz et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.