Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells

BMC Complementary and Alternative Medicine

Mohammad Tariqur Rahman²  Nazmul Haque³  Noor Hayaty Abu Kasim³  Noor Lide Abu Kassim¹  Jazli Aziz² 

[1] Faculty of Dentistry, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Malaysia;Faculty of Science, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Malaysia;Department of Restorative Dentistry, Faculty of Dentistry, University Malaya, Kuala Lumpur 50603, Malaysia

关键词: Stem cell Factor;    Interleukin-6;    Thrombocytes;    Megakaryopoiesis;    Dengue fever;   

Others  :  1220072
DOI  :  10.1186/s12906-015-0749-6

 received in 2015-01-17, accepted in 2015-06-25,  发布年份 2015

【 摘 要 】

Background

Use of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines induction

Methods

In vitro cultures of peripheral blood leukocytes (PBL) and stem cells from human exfoliated deciduous teeth (SHED) were treated with unripe papaya pulp juice (UPJ) to evaluate its potential to induce thrombopoietic cytokines (IL-6 and SCF)

Results

In vitro scratch gap closure was significantly faster (p < .05) in SHED culture treated with UPJ. IL-6 concentration was significantly increased (p < .05) in SHED and PBL culture supernatant when treated with UPJ. SCF synthesis in SHED culture was also significantly increased (p < .05) when treated with UPJ

Conclusion

In vitro upregulated synthesis of IL −6 and SCF both in PBL and SHED reveals the potential mechanism of unripe papaya to induce thrombopoietic cytokines synthesis in cells of hematopoietic and mesenchymal origin.

【 授权许可】

   
2015 Aziz et al.

【 图 表 】

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