Abnormal phosphorylation of Tie2/Akt/eNOS signaling pathway and decreased number or function of circulating endothelial progenitor cells in prehypertensive premenopausal women with diabetes mellitus

BMC Endocrine Disorders

Research Article

Hailin Tang¹  Haitao Zeng²  Zi Ren²  Gaofeng Zeng³  Yanping Jiang³  Zhen Yang⁴ 

[1] Cancer Center, Sun Yat-sen University, 510080, Guangzhou, People’s Republic of China;Center for Reproductive Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, People’s Republic of China;Department of Cardiovascular Medicine, The Second Affiliated Hospital of University of South China, 421001, Hengyang, Hunan, China;Department of Hypertension & Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, People’s Republic of China;

关键词: Prehypertension;    Diabetes mellitus;    Endothelial progenitor cells;    Endothelial function;    Tie2 signaling pathway;   

DOI  :  10.1186/s12902-016-0093-y

 received in 2015-08-28, accepted in 2016-02-25,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundsThe number and activity of circulating endothelial progenitor cells (EPCs) in prehypertension is preserved in premenopausal women. However, whether this favorable effect still exists in prehypertensive premenopausal women with diabetes is not clear.MethodsThis study compared the number and functional activity of circulating EPCs in normotensive or prehypertensive premenopausal women without diabetes mellitus and normotensive or prehypertensive premenopausal women with diabetes mellitus, evaluated the vascular endothelial function in each groups, and investigated the possible underlying mechanism.ResultsWe found that compared with normotensive premenopausal women, the number and function of circulating EPCs, as well as endothelial function evaluated by flow-mediated dilatation (FMD) in prehypertensive premenopausal women were preserved. In parallel, the Tie2/Akt/eNOS signaling pathway and the plasma NO level or NO secretion of circulating EPCs in prehypertensive premenopausal women was also retained. However, in presence of normotension or prehypertension with diabetes mellitus, the number or function of circulating EPCs and FMD in premenopausal women decreased. Similarly, the phosphorylation of Tie2/Akt/eNOS signaling pathway and the plasma NO level or NO secretion of circulating EPCs was reduced in prehypertension premenopausal with diabetes mellitus.ConclusionThe present findings firstly demonstrate that the unfavorable effects of diabetes mellitus on number and activity of circulating EPCs in prehypertension premenopausal women, which is at least partially related to the abnormal phosphorylation of Tie2/Akt/eNOS signaling pathway and subsequently reduced nitric oxide bioavailability. The Tie2/Akt/eNOS signaling pathway may be a potential target of vascular protection in prehypertensive premenopausal women with diabetes mellitus.

【 授权许可】

CC BY   
© Zeng et al. 2016