Maternal hepatitis B virus carrier status and pregnancy outcomes: a prospective cohort study

BMC Pregnancy and Childbirth

Research Article

Jian-Guo Shao¹  Gang Qin²  Hai-Bo Li³  Sheng Zhang⁴  Yi Shen⁴  Xu-Lin Wang⁴  Hai-Yun Liu⁵  Xiao-Yan Cheng⁵  Ai-Ming Cui⁵  Li-Jing Mao⁵  Lei Zhang⁶ 

[1] Center for Liver Diseases, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu, China;Center for Liver Diseases, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu, China;Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, 9 Se-Yuan Road, 226000, Nantong, Jiangsu, China;Department of Clinical Laboratory, The Obstetrics & Gynecology Hospital of Nantong University, Nantong, Jiangsu, China;Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, 9 Se-Yuan Road, 226000, Nantong, Jiangsu, China;Department of Obstetrics, The Obstetrics & Gynecology Hospital of Nantong University, Nantong, Jiangsu, China;Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, VIC, Australia;

关键词: Pregnancy;    Hepatitis B virus infection;    Miscarriage;   

DOI  :  10.1186/s12884-016-0884-1

 received in 2015-11-25, accepted in 2016-04-21,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundInfection with hepatitis B virus (HBV) in pregnant women may be a threat for both mothers and fetuses. This study was performed to explore the impact of maternal HBV carrier status on pregnancy outcomes.MethodsWe conducted a prospective cohort study at the Obstetrics & Gynecology Hospital of Nantong University between January 1, 2012 and September 30, 2015. A consecutive sample of 21,004 pregnant women, 513 asymptomatic HBV carriers and 20,491 non-HBV controls, was included in this study. The main outcomes of interest were selected pregnancy outcomes including miscarriage, stillbirth, preterm birth (PTB), gestational diabetes (GDM), intrahepatic cholestasis of pregnancy (ICP), preterm premature rupture of the membrane (PPROM), low birth weight (LBW), small for gestational age (SGA) and Apgar scores. The incidence of adverse pregnancy outcomes between asymptomatic HBV carriers and non-HBV controls were compared using the chi-square test and logistic regression. P values were two sided, and P <0.05 was considered to indicate statistical significance.ResultsThe incidences of stillbirth, PTB, GDM, ICP, PPROM, LBW, and SGA were similar between the HBV carrier and non-HBV groups. The proportion of miscarriage was significantly higher among the HBV carriers than the controls (9.36 % vs 5.70 %; P <0.001). After using multivariate modelling to adjust for possible socio-demographical variables and obstetric complications, women with HBV carrier status were still more likely to have miscarriage (adjusted OR 1.71, 95 % CI 1.23–2.38). In addition, the incidences of other maternal and neonatal outcomes were similar between the two groups.ConclusionMaternal HBV carrier status may be an independent risk factor for miscarriage and careful surveillance is warranted.

【 授权许可】

CC BY   
© Cui et al. 2016