Vitamin D receptor gene associations with pulmonary tuberculosis in a Tibetan Chinese population

BMC Infectious Diseases

Research Article

Fangping Mo¹  Shilin Xu¹  Guinian Liang¹  Hengxun Zhang¹  Yuhe Wang¹  Longli Kang²  Qunying Hu²  Tianbo Jin³  Zhengshuai Chen⁴ 

[1] Affiliated Hospital of Xizang Minzu University, 712082, Xianyang, Shaanxi, China;Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, 712082, Xianyang, Shaanxi, China;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, 712082, Xianyang, Shaanxi, China;Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, 712082, Xianyang, Shaanxi, China;Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, 712082, Xianyang, Shaanxi, China;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, 712082, Xianyang, Shaanxi, China;Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, 712082, Xianyang, Shaanxi, China;School of Life Sciences, Northwest University, 710069, Xi’an, Shaanxi, China;National Engineering Research Center for Miniaturized Detection Systems, 710069, Xi’an, Shaanxi, China;School of Life Sciences, Northwest University, 710069, Xi’an, Shaanxi, China;National Engineering Research Center for Miniaturized Detection Systems, 710069, Xi’an, Shaanxi, China;

关键词: VDR;    SNP;    Tibetan Chinese population;    PTB;   

DOI  :  10.1186/s12879-016-1699-4

 received in 2015-07-15, accepted in 2016-07-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis.MethodsThis study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi’an. Association analyses of SNPs in VDR were performed with the SPSS 17.0 statistical packages, SNP stats software, Haploview software package (version 4.2), and the SHEsis software platform.ResultsOur results revealed a correlation between three SNPs (rs11574143, odds ratio [OR]: 1.47, 95 % confidence interval [CI]: 1.11 - 1.94, p = 0.006, p-adjust = 0.030; rs11574079, OR: 0.48, 95 % CI: 0.25 - 0.92, p = 0.023, p-adjust = 0.115; rs11168287, OR: 2.55, 95 % CI: 2.00 - 3.25, p = 1.730E-14, p-adjust = 0.865E-13) and PTB based on Chi-square tests. We observed the allele “A” of rs11574143 and rs11168287 increased the PTB risk and the allele “A” of rs11574079 provided a protective effect against PTB.ConclusionsThe goal of this study was the identification of putative associations between five SNPs (rs11574143, rs7975232, rs11574079, rs3819545 and rs11168287) in VDR and susceptibility to PTB. Our findings demonstrated associations between VDR polymorphisms and PTB development.

【 授权许可】

CC BY   
© The Author(s). 2016