Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population

BMC Medical Genetics

Research Article

Zbyněk Šplíchal¹  Monika Goldbergová-Pávková¹  Jan Novák¹  Filip Zlámal²  Ondřej Mikeš²  Aneta Pohořalá²  Julie Bienertová-Vašků³  Hynek Pikhart⁴ 

[1] Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice A18, Brno, Czech Republic;Research Centre for Toxic Compounds in the Environment, Faculty of Sciences, Masaryk University, Kamenice A29, Brno, Czech Republic;Research Centre for Toxic Compounds in the Environment, Faculty of Sciences, Masaryk University, Kamenice A29, Brno, Czech Republic;Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice A18, Brno, Czech Republic;Research Centre for Toxic Compounds in the Environment, Faculty of Sciences, Masaryk University, Kamenice A29, Brno, Czech Republic;Research Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, UK;

关键词: VDR;    SNP;    Obesity;    Anthropometry;    Adiposity;    Gene;    Vitamin D;    Polymorphism;    Adiposity measure;   

DOI  :  10.1186/s12881-017-0454-z

 received in 2017-01-23, accepted in 2017-08-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThere is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.MethodsA total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist–hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.ResultsIn the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (β = −3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (β = −6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (β = −3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (β = −4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (β = −7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too.ConclusionOur study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.

【 授权许可】

CC BY   
© The Author(s). 2017