Bipolar disorders and Wilson’s disease

BMC Psychiatry

Research Article

Krishna M Bhat¹  Gioia Mura²  Luigi Demelia²  Maria Francesca Moro²  Federica Sancassiani²  Mauro Giovanni Carta²  Orazio Sorbello²  Alessandra Serra²  Mario Piga²  Enrico Demelia² 

[1] Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA;University of Cagliari, Italy, Cagliari, Italy;

关键词: Bipolar Disorder;    Mood Disorder;    Panic Disorder;    Serum Copper;    Case Control Design;   

DOI  :  10.1186/1471-244X-12-52

 received in 2012-03-24, accepted in 2012-05-08,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to determine the risk for Bipolar Disorder (BD) in Wilson’s disease (WD) and to measure the impaired Quality of Life (QL) in BD with WD using standardized psychiatric diagnostic tools and a case control design.MethodsThis was a case control study. The cases were 23 consecutive patients with WD treated at the University Hospital in Cagliari, Italy, and the controls were 92 sex- and age-matched subjects with no diagnosis of WD who were randomly selected from a database used previously for an epidemiological study. Psychiatric diagnoses according to DSM-IV criteria were determined by physicians using structured interview tools (ANTAS-SCID). QL was measured by means of SF-12.ResultsCompared to controls, WD patients had lower scores on the SF-12 and higher lifetime prevalence of DSM-IV major depressive disorders (OR = 5.7, 95% CI 2.4–17.3) and bipolar disorders (OR = 12.9, 95% CI 3.6–46.3). BD was associated with lower SF-12 in WD patients.ConclusionsThis study was the first to show an association between BD and WD using standardized diagnostic tools and a case control design. Reports in the literature about increased schizophrenia-like psychosis in WD and a lack of association with bipolar disorders may thus have been based on a more inclusive diagnosis of schizophrenia in the past. Our findings may explain the frequent reports of loss of emotional control, hyperactivity, loss of sexual inhibition, and irritability in WD patients. This study was limited by a small sample size.

【 授权许可】

CC BY   
© Carta et al.; licensee BioMed Central Ltd 2012