BMC Psychiatry | |
Sub-threshold depression and antidepressants use in a community sample: searching anxiety and finding bipolar disorder | |
Research Article | |
Filippo Drago1  Filippo Caraci1  Guido Di Sciascio2  Carlo Faravelli3  Krishna M Bhat4  Leonardo Tondo5  Liliana dell'Osso6  Maria Francesca Moro7  Mauro G Carta7  Maria E Lecca7  Maria Carolina Hardoy8  Massimo Casacchia9  Matteo Balestrieri1,10  | |
[1] Department of Drug Sciences, University of Catania, Italy;Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy;Department of Neurology and Psychiatry, Florence University, Firenze, Italy;Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA;Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA;Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy;Department of Public Health, University of Cagliari, Cagliari, Italy;Department of Public Health, University of Cagliari, Cagliari, Italy;Department of Psychiatry, Reald University, Vlore, Albania;Department of Science of Health, University of L'Aquila, L'Aquila, Italy;Inter-University Center for Behavioural Neurosciences, DPMSC, University of Udine, Udine, Italy; | |
关键词: Bipolar Disorder; Anxiety Disorder; Generalize Anxiety Disorder; Depressive Episode; Panic Disorder; | |
DOI : 10.1186/1471-244X-11-164 | |
received in 2011-05-07, accepted in 2011-10-10, 发布年份 2011 | |
来源: Springer | |
【 摘 要 】
BackgroundTo determine the use of antidepressants (ADs) in people with sub-threshold depression (SD); the lifetime prevalence of mania and hypomania in SD and the link between ADs use, bipolarity and anxiety disorders in SD.MethodsStudy design: community survey. Study population: samples randomly drawn, after stratification from the adult population of municipal records. Sample size: 4999 people from seven areas within six Italian regions. Tools: Questionnaire on psychotropic drug consumption, prescription; Structured Clinical Interview NP for DSM-IV modified (ANTAS); Hamilton Depression Rating Scale (HAM-D); Mood Disorder Questionnaire (MDQ); Short Form Health Survey (SF-12). SD definition: HAM-D > 10 without lifetime diagnosis of Depressive Episode (DE).ResultsSD point prevalence is 5.0%. The lifetime prevalence of mania and hypomania episodes in SD is 7.3%. Benzodiazepines (BDZ) consumption in SD is 24.1%, followed by ADs (19.7%). In SD, positive for MDQ and comorbidity with Panic Disorder (PD) or Generalized Anxiety Disorders (GAD) are associated with ADs use, whereas the association between a positive MDQ and ADs use, without a diagnosis of PD or GAD, is not significant. Only in people with DE the well-being (SF-12) is higher among those using first-line antidepressants compared to those not using any medication. In people with SD no significant differences were found in terms of SF-12 score according to drug use.ConclusionsThis study suggests caution in prescribing ADs to people with SD. In people with concomitant anxiety disorders and SD, it should be mandatory to perform a well-designed assessment and evaluate the presence of previous manic or hypomanic symptoms prior to prescribing ADs.
【 授权许可】
CC BY
© Carta et al; licensee BioMed Central Ltd. 2011
【 预 览 】
Files | Size | Format | View |
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RO202311095915102ZK.pdf | 340KB | download |
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