Validation of the Chinese version of the "Mood Disorder Questionnaire" for screening bipolar disorder among patients with a current depressive episode

BMC Psychiatry

Research Article

Zhaoyu Gan¹  Xiaoli Wu¹  Nianhong Guan¹  Zili Han¹  Jinbei Zhang¹  Feici Diao¹  Kanglai Li² 

[1] Psychiatry Department, the Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, China;VIP Department, the Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, China;

关键词: Bipolar Disorder;    Major Depressive Disorder;    Depressive Episode;    Chinese Version;    Chinese Mainland;   

DOI  :  10.1186/1471-244X-12-8

 received in 2011-08-12, accepted in 2012-01-31,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe Mood Disorder Questionnaire (MDQ) is a well-recognized screening tool for bipolar disorder, but its Chinese version needs further validation. This study aims to measure the accuracy of the Chinese version of the MDQ as a screening instrument for bipolar disorder (BPD) in a group of patients with a current major depressive episode.Methods142 consecutive patients with an initial DSM-IV-TR diagnosis of a major depressive episode were screened for BPD using the Chinese translation of the MDQ and followed up for one year. The final diagnosis, determined by a special committee consisting of three trained senior psychiatrists, was used as a 'gold standard' and ROC was plotted to evaluate the performance of the MDQ. The optimal cut-off was chosen by maximizing the Younden's index.ResultsOf the 142 patients, 122 (85.9%) finished the one year follow-up. On the basis of a semi-structured clinical interview 48.4% (59/122) received a diagnosis of unipolar depression (UPD), 36.9% (45/122) BPDII and 14.8% (18/122) BPDI. At the end of the one year follow-up,9 moved from UPD to BPD, 2 from BPDII to UPD, 1 from BPDII to BPDI, the overall rate of initial misdiagnosis was 16.4%. MDQ showed a good accuracy for BPD: the optimal cut-off was 4, with a sensitivity of 0.72 and a specificity of 0.73. When BPDII and BPDI were calculated independently, the optimal cut-off for BPDII was 4, with a sensitivity of 0.70 and a specificity of 0.73; while the optimal cut-off for BPDI was 5, with a sensitivity of 0.67 and a specificity of 0.86.ConclusionsOur results show that the Chinese version of MDQ is a valid tool for screening BPD in a group of patients with current depressive episode on the Chinese mainland.

【 授权许可】

Unknown   
© Gan et al; BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.