Laxative effects of partially defatted flaxseed meal on normal and experimental constipated mice

BMC Complementary and Alternative Medicine

Research Article

Chang Chen¹  Xiaoqi Zhou²  Nianhong Yang²  Qianchun Deng³  Jin'e Yang³  Fenghong Huang³  Qingde Huang³  Jiqu Xu³ 

[1] Department of Gastroenterology, The No.1 Hospital of Yichang, 2 Jiefang Road, 443000, yichang, People’s Republic of China;Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, 430030, Wuhan, People’s Republic of China;Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, 430062, Wuhan, People’s Republic of China;Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, 430062, Wuhan, People’s Republic of China;

关键词: Flaxseed;    Constipation;    Diphenoxylate;    Dietary fibers;    Laxative;   

DOI  :  10.1186/1472-6882-12-14

 received in 2011-11-08, accepted in 2012-03-09,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundConstipation is a very common health problem in the world. Intake of sufficient amount of dietary fibers is a cornerstone in the prevention and treatment of constipation. As a traditional medicine, flaxseed has been used to treat constipation for centuries, but the controlled trials are rare. The purpose of the present study was to assess that whether partially defatted flaxseed meal (PDFM) has the potential role to facilitate fecal output in normal and experimental constipated mice.MethodsAfter supplemented with 2.5%, 5% and 10% (w/w) PDFM (L-, M- and H -PDFM) for 14 days, the constipation models of mice were induced by atropine-diphenoxylate. The small intestinal transit rates, start time of defecation, amount of defecation and wet weight of feces were researched in normal and constipation model mice.ResultsM- and H-PDFM significantly increase small intestinal transit rates in constipation model mice. All dose of PDFM markedly shortened the start time of defecation and M- and H-PDFM significantly increase stool frequency and weight in both normal and constipation model mice.ConclusionsPDFM may be a useful laxative to facilitate fecal output in normal and constipation conditions.

【 授权许可】

Unknown   
© Xu et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.