Amelioration of intestinal barrier function and reduction of blood lead level in adult women with recurrent spontaneous abortion by a novel product of dietary fiber mixture, Holofood

Journal of Health, Population and Nutrition

Research

Shuhua Wu¹  Tianqin Deng¹  Zhihong Fu¹  Liling Lan¹  Qingzhi Liu²  B. J. Yang Lee³  Meilan Cao⁴  Weizhou Wang⁵  Ting Zhao⁶  Ye Tian⁷  Ruifu Yang⁸  Zhiyuan Pan⁸  Yujing Bi⁸  Yuxiao Chang⁸ 

[1] Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No. 3012, Fuqiang Road, Futian District, 518028, Shenzhen, China;Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No. 3012, Fuqiang Road, Futian District, 518028, Shenzhen, China;Center of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, 518053, Shenzhen, China;Beijing Future Science & Technology Development Co., Ltd., Rm. 1702A #1 Guanhu International Plaza, 105 Yaojiayuan Road, Chaoyang District, 100025, Beijing, China;Center of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, 518053, Shenzhen, China;Department of Obstetrics and Gynecology, The Seventh Medical Center of Chinese People’s Liberation Army General Hospital, 100007, Beijing, China;Guangzhou First People’s Hospital, 510180, Guangzhou, China;Reproductive Medicine Center, Department of Obstetrics and Gynecology, Chinese People’s Liberation Army General Hospital, 100853, Beijing, China;Shenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, 518053, Shenzhen, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China;

关键词: Recurrent spontaneous abortion;    Intestinal barrier integrity;    Lead;    Dietary fibers;    -lactate;    Diamine oxidase;   

DOI  :  10.1186/s41043-023-00394-2

 received in 2023-04-06, accepted in 2023-05-29,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe elevated circulating toxins secondary to the impairment of intestinal barrier integrity commonly elicit a chronic inflammatory response and finally contribute to multiple diseases. These toxins, including bacterial by-products and heavy metals, are the potent risk factors for the development of recurrent spontaneous abortion (RSA). Preclinical evidence suggests that several dietary fibers can restore intestinal barrier function and decrease the accumulation of heavy metals. However, it is uncertain whether treatment with a newly developed blend of dietary fibers product (Holofood) benefits patients with RSA.MethodsIn this trial, we enrolled 70 adult women with RSA, who were randomly assigned into the experiment group and the control group in a 2:1 ratio. Upon the basis of conventional therapy, subjects in the experiment group (n = 48) received 8 weeks oral administration with Holofood three times daily at a dose of 10 g each time. Subjects without Holofood consumption were set as the control (n = 22). Blood samples were collected for the determinations of metabolic parameters, heavy mental lead, and the indices related to intestinal barrier integrity (d-lactate, bacterial endotoxin, and diamine oxidase activity).ResultsThe reduction amplitude in blood lead from baseline to week 8 was 40.50 ± 54.28 (μg/L) in the experiment group as compared with 13.35 ± 36.81 (μg/L) in the control group (P = 0.037). The decreased level of serum d-lactate from baseline to week 8 was 5.58 ± 6.09 (mg/L) in the experiment group as compared with − 2.38 ± 8.90 (mg/L, P < 0.0001) in the control group. The change in serum DAO activity from baseline to week 8 was 3.26 ± 2.23 (U/L) in the experiment group as compared with − 1.24 ± 2.22 (U/L, P < 0.0001) in the control group. Participants who received Holofood had a greater decline in blood endotoxin from baseline to week 8 than those in the control group. Moreover, by comparing with the self-baseline, Holofood consumption significantly decreased the blood levels of lead, d-lactate, bacterial endotoxin, and DAO activity.ConclusionOur results suggest that Holofood affords a clinically relevant improvements in blood lead level and intestinal barrier dysfunction in patients with RSA.

【 授权许可】

CC BY   
© The Author(s) 2023