Assessment of herbal drugs for promising anti-Candida activity

BMC Complementary and Alternative Medicine

Research Article

Ali A. El-Keblawy¹  Mohammad H. Semreen²  Sameh S. M. Soliman³  Priya Uppuluri⁴  Ashraf S. Ibrahim⁴  Arbab Abdullah⁵ 

[1] Department of Applied Biology, University of Sharjah, Sharjah, United Arab Emirates;Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, PO Box 27272, Sharjah, United Arab Emirates;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates;Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, PO Box 27272, Sharjah, United Arab Emirates;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates;Permanent address: Department of Pharmacognosy, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt;Division of Infectious Diseases, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA;David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;University Hospital Sharjah, Sharjah, United Arab Emirates;

关键词: Candida albicans;    Antimicrobial;    Medicinal plant;    Toxicity;    Activity;    Biofilm;   

DOI  :  10.1186/s12906-017-1760-x

 received in 2017-01-13, accepted in 2017-04-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMicrobial infections are diverse and cause serious human diseases. Candida albicans infections are serious healthcare-related infections that are complicated by its morphological switching from yeast to hyphae, resistant biofilm formation and mixed infections with bacteria. Due to the increase in drug resistance to currently used antimicrobial agents and the presence of undesirable side effects, the need for safe and effective novel therapies is important. Compounds derived from plants are known for their medicinal properties including antimicrobial activities. The purpose of the study was to compare and evaluate the anti-Candida activities of several medicinal plants in order for the selection of a herbal drug for human use as effective antimicrobial. The selection was taking into considerations two important parameters; parameters related to the selected drug including activity, stability, solubility and toxicity and parameters related to the pathogen including its different dynamic growth and its accompanied secondary bacterial infections.MethodsSeven different plants including Avicennia marina (Qurm), Fagonia indica (Shoka’a), Lawsania inermis (Henna), Portulaca oleracea (Baq’lah), Salvadora persica (Souwak), Ziziphus spina- Christi (Sidr) and Asphodelus tenuifolius (Kufer) were ground and extracted with ethanol. The ethanol extracts were evaporated and the residual extract dissolved in water prior to testing against Candida albicans in its different morphologies. The antibacterial and cytotoxic effects of the plants extracts were also tested.ResultsOut of the seven tested plants, L. inermis and P. oleracea showed significant anti-Candida activity with MIC ~10 μg/mL. Furthermore, both plant extracts were able to inhibit C. albicans growth at its dynamic growth phases including biofilm formation and age resistance. Accompanied secondary bacterial infections can complicate Candida pathogenesis. L. inermis and P. oleracea extracts showed effective antibacterial activities against S. aureus, P. aeruginosa, E. coli, and the multidrug resistant (MDR) A. baumannii and Klebsiella pneumoniae. Both extracts showed no toxicity when measured at their MIC on human erythrocytes.ConclusionThe results from this study suggested that L. inermis and P. oleracea extracts and/or their chemicals are likely to be promising drugs for human use against C. albicans and MDR bacteria.

【 授权许可】

CC BY   
© The Author(s). 2017