The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population

BMC Public Health

Research Article

Yun Qian¹  Yudi Lin¹  Jianling Bai²  Hongbing Shen²  Feng Chen²  Tiemei Zhang³  Yi Zhang³  Senlin Luo⁴ 

[1] Department of Disease Control and Prevention, Wuxi Center for Disease Prevention and Control, 214023, Wuxi, Jiangsu, China;Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, 210029, Nanjing, Jiangsu, China;Department of Epidemiology, Institute of Geriatrics of Beijing Hospital, Ministry of Health, 100730, Beijing, China;Department of Information, Beijing Institute of Technology, 100081, Beijing, China;

关键词: Body Mass Index;    Total Cholesterol;    Fast Plasma Glucose;    Chinese Population;    Impaired Fasting Glucose;   

DOI  :  10.1186/1471-2458-10-139

 received in 2009-09-04, accepted in 2010-03-17,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundDifferent populations have diverse patterns of relationships between Impaired Fasting Glucose (IFG) and obesity and lipid markers, it is important to investigate the characteristics of associations between IFG and other related risk factors including body mass index (BMI), waist circumstance (WC), serum lipids and blood pressure (BP) in a Chinese population.MethodsThis was a case-control study of 648 IFG subjects and 1,296 controls derived from a large-scale, community-based, cross-sectional survey of 10,867 participants. Each subject received a face-to-face interview, physical examination, and blood tests, including fasting blood glucose and lipids. Student's t-test, Chi-square test, Spearman correlation and multiple logistic regressions were used for the statistical analyses.ResultsFasting plasma glucose (FPG) was positively correlated with BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), and total cholesterol (TC), and was negatively correlated with high density lipoprotein-cholesterol (HDL-C) (all p < 0.05). BMI was more strongly correlated with IFG than with WC. The correlation coefficient of FPG was remarkably higher with TG (0.244) than with TC (0.134) and HDL-C (-0.192). TG was an important predictor of IFG, with odds ratios of 1.76 (95%CI: 1.31-2.36) for subjects with borderline high TG level (1.70 mmol/l ≤ TG < 2.26 mmol/l) and 3.13 (95% CI: 2.50-3.91) for those with higher TG level (TG ≥ 2.26 mmol/l), when comparing to subjects with TG < 1.70 mmol/l. There was a significant dose-response relationship between the number of abnormal variables and increased risk of IFG.ConclusionsIn this Chinese population, both BMI and WC were important predictors of IFG. Abnormal TG as a lipid marker was more strongly associated with IFG than were TC and HDL-C. These factors should be taken into consideration simultaneously for prevention of IFG.

【 授权许可】

CC BY   
© Qian et al; licensee BioMed Central Ltd. 2010