Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: a retrospective cross-sectional study

BMC Pulmonary Medicine

Research Article

David W. Reid¹  Timothy J. Kidd²  Scott C. Bell³  Michelle E. Wood³  Laura J. Sherrard⁴  Kay A. Ramsay⁵  Stephanie T. Yerkovich⁶ 

[1] Adult Cystic Fibrosis Centre, The Prince Charles Hospital, 627 Rode Road, Chermside, 4032, Brisbane, QLD, Australia;Lung Inflammation and Infection Group, QIMR Berghofer Medical Research Institute, 300 Herston Road, 4006, Brisbane, QLD, Australia;Centre for Experimental Medicine, The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, 97 Lisburn Road, BT9 7BL, Belfast, UK;School of Chemistry and Molecular Biosciences, The University of Queensland, 288 Herston Road, 4072, Brisbane, QLD, Australia;Lung Bacteria Group, QIMR Berghofer Medical Research Institute, 300 Herston Road, 4006, Brisbane, QLD, Australia;Adult Cystic Fibrosis Centre, The Prince Charles Hospital, 627 Rode Road, Chermside, 4032, Brisbane, QLD, Australia;School of Medicine, The University of Queensland, 288 Herston Road, 4006, Brisbane, QLD, Australia;Lung Bacteria Group, QIMR Berghofer Medical Research Institute, 300 Herston Road, 4006, Brisbane, QLD, Australia;CF & Airways Microbiology Group, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, BT9 7BL, Belfast, UK;Lung Bacteria Group, QIMR Berghofer Medical Research Institute, 300 Herston Road, 4006, Brisbane, QLD, Australia;School of Medicine, The University of Queensland, 288 Herston Road, 4006, Brisbane, QLD, Australia;School of Medicine, The University of Queensland, 288 Herston Road, 4006, Brisbane, QLD, Australia;Queensland Lung Transplant Service, The Prince Charles Hospital, 4032, Brisbane, QLD, Australia;

关键词: MRSA;    Cystic fibrosis;    Employment;    Incidence;    Nosocomial infection;   

DOI  :  10.1186/s12890-016-0243-z

 received in 2015-11-05, accepted in 2016-05-01,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPeople with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf).MethodsData was collected in this observational study on MRSA acquisition from 405 CF patients attending an adult CF centre in Australia between 2001–2012. Demographic and clinical characteristics were compared between HCWcf and non-HCWcf. A sub-analysis was subsequently performed to compare demographic and clinical characteristics between those patients (HCWcf versus non-HCWcf) that acquired MRSA. We also investigated rates of chronic MRSA infection and the outcome of eradication treatment in HCWcf.ResultsA higher proportion of HCWcf acquired MRSA [n = 10/21] compared to non-HCWcf [n = 40/255] (P <0.001). The odds of MRSA acquisition were 8.4 (95 % CI, 3.0 – 23.4) times greater in HCWcf than non-HCWcf. HCWcf with MRSA were older (P = 0.02) and had better lung function (P = 0.009), yet hospitalisation rates were similar compared to non-HCWcf with MRSA. Chronic MRSA infection developed in 36/50 CF patients (HCWcf, n = 6; non-HCWcf, n = 30), with eradication therapy achieved in 5/6 (83 %) HCWcf.ConclusionsThe rate of MRSA incidence was highest in HCWcf and the workplace is a possible source of acquisition. Vocational guidance should include the potential for MRSA acquisition for CF patients considering healthcare professions.

【 授权许可】

CC BY   
© Wood et al. 2016