Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis

BMC Infectious Diseases

Research Article

Anneclaire J. De Roos¹  Kevin J. Psoter²  Jon Wakefield³  Jonathan D. Mayer⁴  Margaret Rosenfeld⁵ 

[1] Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA, USA;Department of Pediatrics, School of Medicine, The Johns Hopkins University Bayview Medical Center, 5200 Eastern Ave, Mason F. Lord Bldg, Suite 4200, 21224, Baltimore, MD, USA;Departments of Biostatistics and Statistics, University of Washington, Seattle, WA, USA;Departments of Epidemiology, Geography, Global Health, Medicine (Allergy and Infectious Diseases), Family Medicine, and Health Services, University of Washington, Seattle, WA, USA;Division of Pulmonary Medicine, University of Washington School of Medicine, Seattle, WA, USA;Department of Pediatrics, Seattle Children’s Hospital, Seattle, WA, USA;

关键词: Cystic fibrosis;    Seasonality;    MRSA;    Stenotrophomonas maltophilia;    Achromobacter xylosoxidans;   

DOI  :  10.1186/s12879-017-2511-9

 received in 2016-11-08, accepted in 2017-06-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSeasonal variations are often observed for respiratory tract infections; however, limited information is available regarding seasonal patterns of acquisition of common cystic fibrosis (CF)-related respiratory pathogens. We previously reported differential seasonal acquisition of Pseudomonas aeruginosa in young children with CF and no such variation for methicillin-susceptible Staphylococcus aureus acquisition. The purpose of this study was to describe and compare the seasonal incidence of acquisition of other respiratory bacterial pathogens in young children with CF.MethodsWe conducted a retrospective study to describe and compare the seasonal incidence of methicillin-resistant Staphylococcus aureus (MRSA), Stenotrophomonas maltophilia, Achromobacter xylosoxidans, and Haemophilus influenzae acquisition in young CF patients residing in the U.S. using the Cystic Fibrosis Foundation National Patient Registry, 2003-2009. Log-linear overdispersed Poisson regression was used to evaluate seasonal acquisition of each of these pathogens.ResultsA total of 4552 children met inclusion criteria. During follow-up 910 (20%), 1161 (26%), 228 (5%), and 2148 (47%) children acquired MRSA, S. maltophilia, A. xylosoxidans and H. influenzae, respectively. Compared to winter season, MRSA was less frequently acquired in spring (Incidence Rate Ratio [IRR]: 0.79; 95% Confidence Interval [CI]: 0.65, 0.96) and summer (IRR: 0.69; 95% CI: 0.57, 0.84) seasons. Similarly, a lower rate of A. xylosoxidans acquisition was observed in spring (IRR: 0.59; 95% CI: 0.39, 0.89). For H. influenzae, summer (IRR: 0.88; 95% CI: 0.78, 0.99) and autumn (IRR: 0.78; 95% CI: 0.69, 0.88) seasons were associated with lower acquisition rates compared to winter. No seasonal variation was observed for S. maltophilia acquisition.ConclusionAcquisition of CF-related respiratory pathogens displays seasonal variation in young children with CF, with the highest rate of acquisition for most pathogens occurring in the winter. Investigation of factors underlying these observed associations may contribute to our understanding of the aetiology of these infections and guide future infection control strategies.

【 授权许可】

CC BY   
© The Author(s). 2017