Is there a relation between pre-sarcopenia, sarcopenia, cachexia and osteoporosis in patients with ankylosing spondylitis?

BMC Musculoskeletal Disorders

Research Article

François Bertin Ebo’o¹  Siham Sadni¹  Aziza Mounach¹  Toufik Hamza¹  Abderrahim Majjad¹  Abdellah El Maghraoui¹ 

[1] Rheumatology Department, Military Hospital Mohammed V, Rabat, University Mohammed V Souissi, PO Box: 1018, Rabat, Morocco;

关键词: Ankylosing spondylitis;    Sarcopenia;    Cachexia;    Osteoporosis;    DXA;    Body composition;   

DOI  :  10.1186/s12891-016-1155-z

 received in 2016-03-18, accepted in 2016-07-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundOsteoporosis is a well-known complication of ankylosing spondylitis (AS). However, data about body composition modifications and muscle performance showed conflicting results. The aim of the study was to determine the prevalence and risk factors of pre-sarcopenia, sarcopenia and cachexia in patients with AS and analyze its relationship with bone loss and symptomatic and severity parameters of the disease.MethodsSixty-seven consecutive male patients with AS (mean age of 40.9 ± 11.0 years) and 67 healthy controls were studied. Body composition and bone mineral density (BMD) scans were obtained using DXA. The fat-free mass index (FFMI; fat-free mass divided by height squared) and the percent of fat mass (%FM) were calculated. Pre-sarcopenia was defined by low skeletal muscle mass (SMI <7.25 kg/m2), sarcopenia by the combined presence of the two following criteria: SMI <7.25 kg/m2 and a low muscle strength (handgrip strength <30 kg) or a low muscle performance (timed get-up-and-go test >10 s) and cachexia by a BMI <20 kg/m2 plus 3 from the 5 following parameters: anorexia, fatigue, handgrip strength <30 kg, CRP >5 mg/l, SMI <7.25 kg/m2.ResultsPre-sarcopenia, sarcopenia, cachexia, and osteoporosis prevalences were (50.4, 34.3, 11.9, and 16.0) respectively. Patients had a mean 3 kg significant decrease in FFM and a 1 kg/m2 decrease in appendicular mass vs. healthy controls. Pre-sarcopenia, sarcopenia and cachexia were significantly associated to higher BASDAI levels and low BMD.ConclusionOur study showed that men with AS had a statistically significant reduction in total and appendicular lean mass that is related to higher disease activity and significantly associated to bone loss.

【 授权许可】

CC BY   
© The Author(s). 2016