Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma

BMC Cancer

Research Article

Xin-Ming Guo¹  Pei-Hong Wu²  Lu-Jun Shen²  Qi Zeng²  Xiang Guo³  Chao-Nan Qian³ 

[1] Department of Pharmacy, the Fifth Affiliated Hospital, Sun Yat-sen University, 519000, Zhuhai, PR China;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, 510060, Guangzhou, China;Department of Medical Imaging and Interventional Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, PR China;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, 510060, Guangzhou, China;Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, PR China;

关键词: Weight loss;    Nasopharyngeal carcinoma;    Radiotherapy;    Survival;   

DOI  :  10.1186/s12885-016-2214-4

 received in 2015-10-08, accepted in 2016-02-24,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe impacts of weight loss on prognosis in nasopharyngeal carcinoma (NPC) remain unclear. The present study was therefore undertaken to investigate the association between critical weight loss and long-term survival in NPC patients.MethodsThe eligible 2399 NPC patients were reviewed. Weight change was categorized into critical weight loss (CWL) and non-critical weight loss (Non-CWL). The associations of CWL with long-term survival were analyzed by Cox regression in the entire patient and two subsets. Propensity score matching was performed to reduce the effects of confounding factors.ResultsCWL was defined as body weight loss of ≥4.6 %. Compared with patients without CWL, patients with CWL had significantly lower 5-year OS (72.4 vs. 79.3 %, P < 0.001), FFS (71.1 vs. 78.4 %, P <0.001), and LR-FFS (78.1 vs. 84.8 %, P <0.001), respectively. After adjustment for potential confounders, CWL remained an independence prognostic factor for OS (HR = 1.352; 95 % CI 1.160–1.576; P < 0.001), FFS (HR = 3.275; 95 % CI 1.101–9.740; P = 0.033), and LR-FFS (HR = 6.620; 95 % CI 2.990–14.658; P < 0.001), respectively. Furthermore, subgroup analysis in the cohort of patients received concurrent chemoradiotherapy or radiotherapy alone confirmed the results in the entire patient even after the propensity-score matching. In IMRT cohort, CWL was also significantly associated with a lower OS (P = 0.04) and FFS (P = 0.04).ConclusionsCWL has a significant and independent impact on long-term survival in nasopharyngeal carcinoma patients.

【 授权许可】

CC BY   
© Zeng et al. 2016