Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

BMC Complementary and Alternative Medicine

Research Article

Jooil Yi¹  Byung-Cheol Lee¹  Sang Yeol Song¹  Sang Hyub Lee²  Young Ock Kim³  Sang Wook Kang⁴  Hosik Seok⁴  Su Kang Kim⁴  Hae Jeong Park⁴  Hye Sook Jeon⁴  Joo-Ho Chung⁴ 

[1] Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 130-702, Seoul, Republic of Korea;Department of Urology, College of Medicine, Kyung Hee University, 130-702, Seoul, Republic of Korea;Development of Ginseng and Medical Plants Research Institute, Rural Administration, 369-873, Eumseong, Republic of Korea;Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 130-701, Seoul, Republic of Korea;

关键词: Curcumin;    Benign prostatic hyperplasia;    Testosterone;    BPH;   

DOI  :  10.1186/s12906-015-0825-y

 received in 2013-11-15, accepted in 2015-08-25,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundBenign prostatic hyperplasia (BPH) is one of the common male diseases, which is provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects of prevention and treatment to diseases. We investigated whether curcumin may repress the development of BPH in male Wistar rats.MethodsSeven weeks male Wistar rats were and divided into 4 groups (normal group, BPH group, finasteride group, curcumin group; n = 8 for each group). In order to induce BPH in rats, rats were castrated and testosterone was injected subcutaneously everyday (s.c., 20 mg/kg). Rats in the curcumin group were treated 50 mg/kg, administered orally for 4 weeks. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed.ResultsCompared to the finasteride group as positive group, the curcumin group showed similarly protective effect on BPH in histopathologic morphology, prostate volume. Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ß1, and IGF1 were also decreased in the curcumin group.ConclusionsThese results suggested that curcumin inhibited the development of BPH and might a useful herbal treatment or functional food for BPH.

【 授权许可】

CC BY   
© Kim et al. 2015