The Diabetes Pearl: Diabetes biobanking in The Netherlands

BMC Public Health

Study Protocol

Hanno Pijl¹  Marja W Dijk-Schaap¹  Nicolaas C Schaper²  Bruce HR Wolffenbuttel³  Wanda M Admiraal⁴  Frits Holleman⁴  Behiye Özcan⁵  Eric JG Sijbrands⁵  Miranda T Schram⁶  Coen DA Stehouwer⁶  Cees J Tack⁷  Evertine J Abbink⁷  Bianca Silvius⁸  Harold W de Valk⁸  Esther van’t Riet⁹  Jacqueline M Dekker⁹  Giel Nijpels^1,10 

[1] Department of Edocrinology & Metabolism, Leiden University Medical Center, Leiden, The Netherlands;Department of Endocrinology, Maastricht University Medical Center, Maastricht, The Netherlands;School for Public Health and Primary Care, Maastricht University Medical Center, Maastricht, The Netherlands;Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands;Department of Internal Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands;Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands;Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands;Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands;Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands;Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands;VU University Medical Center, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands;Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands;VU University Medical Center, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands;Department of General Practice, VU University Medical Center, Amsterdam, The Netherlands;

关键词: Design;    Biobank;    Research infrastructure;    Type 2 diabetes;    The Netherlands;   

DOI  :  10.1186/1471-2458-12-949

 received in 2012-09-27, accepted in 2012-10-22,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundType 2 diabetes is associated with considerable comorbidity and severe complications, which reduce quality of life of the patients and require high levels of healthcare. The Diabetes Pearl is a large cohort of patients diagnosed with type 2 diabetes, covering different geographical areas in the Netherlands. The aim of the study is to create a research infrastructure that will allow the study of risk factors, including biomarkers and genetic determinants for severe diabetes complications.Methods/designBaseline examinations began November 2009 and will continue through 2012. By the end of 2012, it is expected that 7000 patients with type 2 diabetes will be included in the Diabetes Pearl cohort. To ensure quality of the data collected, standard operation procedures were developed and used in all 8 recruitment centers. From all patients who provide informed consent, the following information is collected: personal information, medication use, physical examination (antropometry, blood pressure, electrocardiography (ECG), retina photographs, ankle-brachial index, peripheral vibration perception), self-report questionnaire (socio-economic status, lifestyle, (family) history of disease, and psychosocial well-being), laboratory measurements (glucose, A1c, lipid profile, kidney function), biobank material (storage of urine and blood samples and isolated DNA). All gathered clinical data and biobank information is uploaded to a database for storage on a national level. Biobanks are maintained locally at all recruitment centers.DiscussionThe Diabetes Pearl is large-scale cohort of type 2 diabetes patients in the Netherlands aiming to study risk factors, including biomarkers and genetic markers, for disease deterioration and the development of severe diabetes complications. As a result of the well-designed research design and the national coverage, the Diabetes Pearl data can be of great value to national and international researchers with an interest in diabetes related research.

【 授权许可】

Unknown   
© van't Riet et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.