Psychological and personality factors in type 2 diabetes mellitus, presenting the rationale and exploratory results from The Maastricht Study, a population-based cohort study

BMC Psychiatry

Research Article

Pieter C. Dagnelie¹  Stef P. J. Kremers²  Simone J. S. Sep³  Ronald M. A. Henry³  Carla J. H. van der Kallen³  Miranda T. Schram³  Coen D. A. Stehouwer³  Nicolaas C. Schaper⁴  Fleur E. P. van Dooren⁵  Johan Denollet⁶  Frans Pouwer⁶  Annemarie Koster⁷  Frans R. J. Verhey⁸ 

[1] CARIM Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands;CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands;Department of Epidemiology, Maastricht University, Maastricht, The Netherlands;Department of Health Promotion, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands;Department of Internal Medicine, Maastricht University Medical Centre, Randwycksingel 35, 6229 EG, Maastricht, The Netherlands;CARIM Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands;Department of Internal Medicine, Maastricht University Medical Centre, Randwycksingel 35, 6229 EG, Maastricht, The Netherlands;CARIM Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands;CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands;Department of Internal Medicine, Maastricht University Medical Centre, Randwycksingel 35, 6229 EG, Maastricht, The Netherlands;Department of Medical and Clinical Psychology, CoRPS – Center of Research on Psychology in Somatic diseases, Tilburg University, Tilburg, The Netherlands;MHeNS – Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands;Department of Medical and Clinical Psychology, CoRPS – Center of Research on Psychology in Somatic diseases, Tilburg University, Tilburg, The Netherlands;Department of Social Medicine, Maastricht University, Maastricht, The Netherlands;CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands;MHeNS – Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands;

关键词: Type 2 diabetes;    Cohort;    Design;    Exploratory results;    Depression;    Anxiety;    Personality;   

DOI  :  10.1186/s12888-016-0722-z

 received in 2015-02-05, accepted in 2016-01-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundStrong longitudinal evidence exists that psychological distress is associated with a high morbidity and mortality risk in type 2 diabetes. Little is known about the biological and behavioral mechanisms that may explain this association. Moreover, the role of personality traits in these associations is still unclear. In this paper, we first describe the design of the psychological part of The Maastricht Study that aims to elucidate these mechanisms. Next, we present exploratory results on the prevalence of depression, anxiety and personality traits in type 2 diabetes. Finally, we briefly discuss the importance of these findings for clinical research and practice.MethodsWe measured psychological distress and depression using the MINI diagnostic interview, the PHQ-9 and GAD-7 questionnaires in the first 864 participants of The Maastricht Study, a large, population-based cohort study. Personality traits were measured by the DS14 and Big Five personality questionnaires. Type 2 diabetes was assessed by an oral glucose tolerance test. Logistic regression analyses were used to estimate the associations of depression, anxiety and personality with type 2 diabetes, adjusted for age, sex and education level.ResultsIndividuals with type 2 diabetes had higher levels of depressive and anxiety symptoms, odds ratios (95 % CI) were 3.15 (1.49; 6.67), 1.73 (0.83–3.60), 1.50 (0.72–3.12), for PHQ-9 ≥ 10, current depressive disorder and GAD-7 ≥ 10, respectively. Type D personality, social inhibition and negative affectivity were more prevalent in type 2 diabetes, odds ratios were 1.95 (1.23–3.10), 1.35 (0.93–1.94) and 1.70 (1.14–2.51), respectively. Individuals with type 2 diabetes were less extraverted, less conscientious, less agreeable and less emotionally stable, and similar in openness to individuals without type 2 diabetes, although effect sizes were small.ConclusionsIndividuals with type 2 diabetes experience more psychological distress and have different personality traits compared to individuals without type 2 diabetes. Future longitudinal analyses within The Maastricht Study will increase our understanding of biological and behavioral mechanisms that link psychological distress to morbidity and mortality in type 2 diabetes.

【 授权许可】

CC BY   
© van Dooren et al. 2016