Snail expression and outcome in T1 high-grade and T2 bladder cancer: a retrospective immunohistochemical analysis

BMC Urology

Research Article

Akira Shimizu¹  Mika Terasaki¹  Shunichiro Nomura²  Yasutomo Suzuki²  Tsutomu Hamasaki²  Ryo Takahashi²  Ryoji Kimata²  Go Kimura²  Yukihiro Kondo² 

[1] Analytic Human Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan;Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan;

关键词: Snail;    Bladder cancer;    Prognostic marker;    Chemotherapy;   

DOI  :  10.1186/1471-2490-13-73

 received in 2013-09-20, accepted in 2013-12-16,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundNeoadjuvant chemotherapy has been shown to have benefit in T1 high-grade or T2 bladder cancer. However, neoadjuvant chemotherapy fails in some patients. Careful patient selection for neoadjuvant chemotherapy is therefore needed. Several reports show that Snail is associated with resistance to chemotherapy. We hypothesized that Snail expression could predict survival in T1 high-grade and T2 bladder cancer patients treated with neoadjuvant chemotherapy.MethodsThe participants were 44 patients with T1 high-grade and T2 bladder cancer receiving neoadjuvant chemotherapy. Immunohistochemical analysis was used to determine Snail expression in specimens of bladder cancer obtained by transurethral resection before neoadjuvant chemotherapy. The relationships between Snail expression and patients’ outcomes were analyzed.ResultsSnail expression was positive in 15 of the 44 patients (34.1%) and negative in 29 (65.9%). Disease-free survival was significantly shorter for the Snail-positive group than for the Snail-negative group (p = 0.014). In addition, disease-specific survival was also significantly shorter for the Snail-positive group than for the Snail-negative group (p = 0.039). In multivariate analysis, Snail expression level was identified as an independent prognostic factor for disease-specific survival (p = 0.020).ConclusionsThe results indicate that Snail expression may predict poor outcome in T1 high-grade and T2 bladder cancer patients treated with neoadjuvant chemotherapy.

【 授权许可】

CC BY   
© Nomura et al.; licensee BioMed Central Ltd. 2013