IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis

BMC Musculoskeletal Disorders

Research Article

Daniel Kotrych¹  Violetta Dziedziejko²  Krzysztof Safranow²  Andrzej Pawlik³  Michal Czerewaty³  Damian Malinowski⁴ 

[1] Departament of Orthopaedics, Traumatology and Orthopaedic Oncology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252, Szczecin, Poland;Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland;Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland;Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland;Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland;

关键词: Cytokines;    IL17A;    IL17F;    Polymorphism;    Rheumatoid arthritis;   

DOI  :  10.1186/s12891-016-1064-1

 received in 2015-11-19, accepted in 2016-05-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundInterleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA.MethodsWe examined 422 RA patients and 337 subjects as a control group. Single nucleotide polymorphism (SNP) in the IL17A (rs2275913) and IL17F (rs763780, rs11465553, rs2397084) genes were genotyped using TaqMan genotyping assays from Life Technologies Genomic.ResultsThere were no significant differences in distribution of IL17A and IL17F genotypes and alleles between RA patients and control group. There were no significant associations between IL17A and IL17F genotypes and age of disease diagnosis rheumatoid factor, erosive disease as well as extra-articular manifestations.ConclusionsThe results of this study suggest, that IL17A and IL17F gene polymorphism are not the important factors associated with susceptibility and some clinical parameters of RA in a Polish population.

【 授权许可】

CC BY   
© Pawlik et al. 2016