The Carpathian range represents a weak genetic barrier in South-East Europe

BMC Genetics

Research Article

Montserrat Hervella¹  Neskuts Izagirre¹  Santos Alonso¹  Concepción de-la-Rua¹  Mihai G Netea²  Mihai Ioana³ 

[1] Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Barrio Sarriena s/n, 48940, Leioa, Bizkaia, Spain;Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;University of Medicine and Pharmacy Craiova, Craiova, Romania;

关键词: Mitochondrial DNA;    Carpathian Mountains;    Romanian population;    Genetic barrier;   

DOI  :  10.1186/1471-2156-15-56

 received in 2013-10-29, accepted in 2014-05-07,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIn the present study we have assessed whether the Carpathian Mountains represent a genetic barrier in East Europe. Therefore, we have analyzed the mtDNA of 128 native individuals of Romania: 62 of them from the North of Romania, and 66 from South Romania.ResultsWe have analyzed their mtDNA variability in the context of other European and Near Eastern populations through multivariate analyses. The results show that regarding the mtDNA haplogroup and haplotype distributions the Romanian groups living outside the Carpathian range (South Romania) displayed some degree of genetic differentiation compared to those living within the Carpahian range (North Romania).ConclusionThe main differentiation between the mtDNA variability of the groups from North and South Romania can be attributed to the demographic movements from East to West (prehistoric or historic) that differently affected in these regions, suggesting that the Carpathian mountain range represents a weak genetic barrier in South-East Europe.

【 授权许可】

Unknown   
© Hervella et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.