The Carpathian range represents a weak genetic barrier in South-East Europe

BMC Genetics

Concepción de-la-Rua²  Mihai G Netea³  Mihai Ioana¹  Santos Alonso²  Neskuts Izagirre²  Montserrat Hervella² 

[1] University of Medicine and Pharmacy Craiova, Craiova, Romania;Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Barrio Sarriena s/n 48940, Leioa, Bizkaia, Spain;Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

关键词: Genetic barrier;    Romanian population;    Carpathian Mountains;    Mitochondrial DNA;   

Others  :  866256
DOI  :  10.1186/1471-2156-15-56

 received in 2013-10-29, accepted in 2014-05-07,  发布年份 2014

【 摘 要 】

Background

In the present study we have assessed whether the Carpathian Mountains represent a genetic barrier in East Europe. Therefore, we have analyzed the mtDNA of 128 native individuals of Romania: 62 of them from the North of Romania, and 66 from South Romania.

Results

We have analyzed their mtDNA variability in the context of other European and Near Eastern populations through multivariate analyses. The results show that regarding the mtDNA haplogroup and haplotype distributions the Romanian groups living outside the Carpathian range (South Romania) displayed some degree of genetic differentiation compared to those living within the Carpahian range (North Romania).

Conclusion

The main differentiation between the mtDNA variability of the groups from North and South Romania can be attributed to the demographic movements from East to West (prehistoric or historic) that differently affected in these regions, suggesting that the Carpathian mountain range represents a weak genetic barrier in South-East Europe.

【 授权许可】

   
2014 Hervella et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 5.

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