Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

BMC Musculoskeletal Disorders

Research Article

Rachel C Dirks¹  Stuart J Warden²  Jeffrey S Richard³  Angela M Fearon⁴  Alexander Scott⁴  Lauren G Koch⁵  Steven L Britton⁵ 

[1] Center for Translational Musculoskeletal Research, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA;Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA;Center for Translational Musculoskeletal Research, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA;Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA;Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St, CF-32646202, Indianapolis, IN, USA;Center for Translational Musculoskeletal Research, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA;Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St, CF-32646202, Indianapolis, IN, USA;Centre for Hip Health and Mobility, Vancouver Coastal Health and Research Institute, Vancouver, BC, Canada;Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada;Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA;

关键词: Animal model;    Tendinitis;    Tendinopathy;    Tendinosis;    Overuse;   

DOI  :  10.1186/1471-2474-14-90

 received in 2012-12-29, accepted in 2013-03-06,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.MethodsTwenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.ResultsThere were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).ConclusionsUphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.

【 授权许可】

Unknown   
© Dirks et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.