Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

BMC Musculoskeletal Disorders

Stuart J Warden¹  Steven L Britton²  Lauren G Koch²  Alexander Scott⁴  Angela M Fearon⁴  Jeffrey S Richard¹  Rachel C Dirks³ 

[1] Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St., CF-326, Indianapolis, IN, 46202, USA;Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA;Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA;Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada

关键词: Overuse;    Tendinosis;    Tendinopathy;    Tendinitis;    Animal model;   

Others  :  1133445
DOI  :  10.1186/1471-2474-14-90

 received in 2012-12-29, accepted in 2013-03-06,  发布年份 2013

【 摘 要 】

Background

The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.

Methods

Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.

Results

There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).

Conclusions

Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.

【 授权许可】

   
2013 Dirks et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Fig. 2.

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