No association between polymorphisms/haplotypes of the vascular endothelial growth factor gene and preeclampsia

BMC Pregnancy and Childbirth

Research Article

Augusto Rojas-Martinez¹  Rocio Ortiz-Lopez¹  Claudia Castruita-De la Rosa²  Jose E Rivera-Muñoz²  Elda A Garcia-Mayorga²  Margarita L Martinez-Fierro²  Idalia Garza-Veloz³  Esteban Meza-Lamas⁴  Victoria Martinez-Gaytan⁵  Raul Cortes-Flores⁵ 

[1] Department of Biochemistry and Molecular Medicine, University Hospital Universidad Autonoma de Nuevo Leon, Av. F. I. Madero S/N, Col. Mitras Centro, Monterrey, Mexico;Centro de Investigacion y Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo Leon, Calle Carlos Canseco S/N, Col. Mitras Centro, Monterrey, Mexico;Laboratorio de Medicina Molecular, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6, Ejido la Escondida, Zacatecas, Mexico;Laboratorio de Medicina Molecular, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6, Ejido la Escondida, Zacatecas, Mexico;Department of Biochemistry and Molecular Medicine, University Hospital Universidad Autonoma de Nuevo Leon, Av. F. I. Madero S/N, Col. Mitras Centro, Monterrey, Mexico;Unidad Academica de Enfermeria, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas, Mexico;Unidad Medica Materno-Fetal del Noreste, Unidad Medica de Alta Especialidad No. 23 Instituto Mexicano del Seguro Social, Avenida Constitucion y Felix U. Gomez, Col. Centro, Monterrey, Mexico;

关键词: Vascular Endothelial Growth Factor;    Preeclampsia;    Gestational Diabetes Mellitus;    Gestation Week;    Spiral Artery;   

DOI  :  10.1186/1471-2393-11-35

 received in 2011-01-18, accepted in 2011-05-16,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundPreeclampsia (PE) is the first worldwide cause of death in pregnant women, intra-uterine growth retardation, and fetal prematurity. Some vascular endothelial grown factor gene (VEGF) polymorphisms have been associated to PE and other pregnancy disturbances. We evaluated the associations between VEGF genotypes/haplotypes and PE in Mexican women.Methods164 pregnant women were enrolled in a case-control study (78 cases and 86 normotensive pregnant controls). The rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (+405G/C), and rs25648 (-7C/T), VEGF variants were discriminated using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) methods or Taqman single nucleotide polymorphism (SNP) assays.ResultsThe proportions of the minor allele for rs699947, rs1570360, rs2010963, and rs25648 VEGF SNPs were 0.33, 0.2, 0.39, and 0.17 in controls, and 0.39, 0.23, 0.41, and 0.15 in cases, respectively (P values > 0.05). The most frequent haplotypes of rs699947, rs1570360, rs2010963, and rs25648 VEGF SNPs, were C-G-C-C and C-G-G-C with frequencies of 0.39, 0.21 in cases and 0.37, 0.25 in controls, respectively (P values > 0.05)ConclusionThere was no evidence of an association between VEGF alleles, genotypes, or haplotypes frequencies and PE in our study.

【 授权许可】

Unknown   
© Garza-Veloz et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.