Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study

BMC Gastroenterology

Research Article

Veerle M H Coupe¹  Chris J J Mulder²  Roy L J van Wanrooij²  Greetje J Tack²  Petra Bonnet³  B Mary E Von Blomberg³  Hedayat Amini³  Marco W J Schreurs⁴ 

[1] Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands;Department of Gastroenterology and Hepatology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands;Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands;Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands;Department of Immunology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands;

关键词: Coeliac disease;    Refractory coeliac disease;    Enteropathy associated T-cell lymphoma;    Cytokines;    Immunological and biochemical parameters;   

DOI  :  10.1186/1471-230X-12-159

 received in 2012-05-21, accepted in 2012-11-04,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundInvasive techniques are still required to distinguish between uncomplicated and complicated forms of CD.MethodsWe set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy associated T-cell lymphoma (EATL).ResultsIn both active CD and RCDI-II elevated levels of the proinflammatory IL-8, IL-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups.ConclusionsA series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.

【 授权许可】

CC BY   
© Tack et al.; licensee BioMed Central Ltd. 2012