Minocycline reduces reactive gliosis in the rat model of hydrocephalus

BMC Neuroscience

Research Article

Zhanxiang Wang¹  Caiquan Huang¹  Feng Liu¹  Hongwei Zhu¹  Feifei Zhang¹  Shaolin Zhang²  Hao Xu²  Guowei Tan³ 

[1]Department of Neurosurgery, First Affiliate Hospital of Xiamen University, 361003, Xiamen, Fujian Province, China

[2]Department of Neurosurgery, First Affiliate Hospital of Xiamen University, 361003, Xiamen, Fujian Province, China

[3]Medical College of Xiamen University, 361003, Xiamen, Fujian Province, China

[4]Department of Neurosurgery, First Affiliate Hospital of Xiamen University, 361003, Xiamen, Fujian Province, China

[5]School of Life Science, Xiamen University, 361003, Xiamen, Fujian Province, China

关键词: Hydrocephalus;    Gliosis;    Astrocytosis;    Microgliosis;    Minocycline;   

DOI  :  10.1186/1471-2202-13-148

 received in 2012-05-29, accepted in 2012-11-23,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundReactive gliosis had been implicated in injury and recovery patterns associated with hydrocephalus. Our aim is to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties, to reduce reactive gliosis and inhibit the development of hydrocephalus.ResultsThe ventricular dilatation were evaluated by MRI at 1-week post drugs treated, while GFAP and Iba-1were detected by RT-PCR, Immunohistochemistry and Western blot. The expression of GFAP and Iba-1 was significantly higher in hydrocephalic group compared with saline control group (p < 0.05). Minocycline treatment of hydrocephalic animals reduced the expression of GFAP and Iba-1 significantly (p < 0.05). Likewise, the severity of ventricular dilatation is lower in minocycline treated hydrocephalic animals compared with the no minocycline group (p < 0.05).ConclusionMinocycline treatment is effective in reducing the gliosis and delaying the development of hydrocephalus with prospective to be the auxiliary therapeutic method of hydrocephalus.

【 授权许可】

Unknown   
© Xu et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.