BMC Neuroscience | |
Minocycline reduces reactive gliosis in the rat model of hydrocephalus | |
Zhanxiang Wang3  Feifei Zhang3  Caiquan Huang3  Feng Liu3  Hongwei Zhu3  Shaolin Zhang1  Guowei Tan2  Hao Xu1  | |
[1] Medical College of Xiamen University, Xiamen, Fujian Province, 361003, China;School of Life Science, Xiamen University, Xiamen, Fujian Province, 361003, China;Department of Neurosurgery, First Affiliate Hospital of Xiamen University, Xiamen, Fujian Province, 361003, China | |
关键词: Minocycline; Microgliosis; Astrocytosis; Gliosis; Hydrocephalus; | |
Others : 1140697 DOI : 10.1186/1471-2202-13-148 |
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received in 2012-05-29, accepted in 2012-11-23, 发布年份 2012 | |
【 摘 要 】
Background
Reactive gliosis had been implicated in injury and recovery patterns associated with hydrocephalus. Our aim is to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties, to reduce reactive gliosis and inhibit the development of hydrocephalus.
Results
The ventricular dilatation were evaluated by MRI at 1-week post drugs treated, while GFAP and Iba-1were detected by RT-PCR, Immunohistochemistry and Western blot. The expression of GFAP and Iba-1 was significantly higher in hydrocephalic group compared with saline control group (p < 0.05). Minocycline treatment of hydrocephalic animals reduced the expression of GFAP and Iba-1 significantly (p < 0.05). Likewise, the severity of ventricular dilatation is lower in minocycline treated hydrocephalic animals compared with the no minocycline group (p < 0.05).
Conclusion
Minocycline treatment is effective in reducing the gliosis and delaying the development of hydrocephalus with prospective to be the auxiliary therapeutic method of hydrocephalus.
【 授权许可】
2012 Xu et al.; licensee BioMed Central Ltd.
【 预 览 】
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