HPV and cofactors for invasive cervical cancer in Morocco: a multicentre case-control study

BMC Cancer

Research Article

Mohammed El-Mzibri¹  Mohammed Attaleb¹  Zinab Qmichou²  Karima Bendahhou³  Noureddine Matar⁴  Abdelatif Benideer⁵  Noureddine Benjaafar⁶  Majdouline Obtel⁷  Abdelhai Filali Adib⁸  Rachid Bezad⁹  Naima Abda^1,10  Mohamed Berraho^1,10  Chakib Nejjari^1,10  Kaoutar Znati^1,11  Hind El Fatemi^1,11  Afaf Amarti-Riffi^1,11  Simone Mathoulin-Pelissier^1,12 

[1] Biology Unit and Medical Research, National Center of Energy, Sciences and Nuclear Techniques (CNESTEN), Rabat, Morocco;Biology Unit and Medical Research, National Center of Energy, Sciences and Nuclear Techniques (CNESTEN), Rabat, Morocco;Faculty of Science and technology, Mohammedia, Morocco;Cancer Registry of Casablanca, Casablanca, Morocco;Department of Gynecology and Obstetrics, CHU IbnRochd, Casablanca, Morocco;Department of Oncology-Radiotherapy, CHU IbnRochd, Casablanca, Morocco;Department of Radiotherapy, National Institute of Oncology, Rabat, Morocco;Directorate of Epidemiology and Fight against Disease (DELM) Ministry of Health, Rabat, Morocco;Hospital “Les Orangers”, CHU IbnSina, Rabat, Morocco;Hospital “Les Orangers”, CHU IbnSina, Rabat, Morocco;Faculty of Medicine and Pharmacy, University Mohammed V Souissi, Rabat, Morocco;Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy, University Sidi Mohammed Benabdellah, BP.1893, Km 2.2 Route Sidi Harazem, Fez, Morocco;Pathological Anatomy Laboratory, CHU Hassan-II, Fez, Morocco;Univ. Bordeaux, ISPED, Centre INSERM U897 – Epidemiologie-Biostatistique, F-33000, Bordeaux, France;CIC-EC7, Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Centre, Bordeaux, France;

关键词: Cervical cancer;    Hpv;    Determinants;    Case-control study;    Morocco;   

DOI  :  10.1186/s12885-017-3425-z

 received in 2015-10-06, accepted in 2017-06-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundLimited national information is available in Morocco on the prevalence and distribution of HPV-sub-types of cervical cancer and the role of other risk factors. The aim was to determine the frequency of HPV-sub-types of cervical cancer in Morocco and investigate risk factors for this disease.MethodsBetween November 2009 and April 2012 a multicentre case-control study was carried out. A total of 144 cases of cervical cancer and 288 age-matched controls were included. Odds-ratios and corresponding confidence-intervals were computed by conditional logistic regression models.ResultsCurrent HPV infection was detected in 92.5% of cases and 13.9% of controls. HPV16 was the most common type for both cases and controls. Very strong associations between HPV-sub-types and cervical cancer were observed: total-HPV (OR = 39), HPV16 (OR = 49), HPV18 (OR = 31), and multiple infections (OR = 13). Education, high parity, sexual intercourse during menstruation, history of sexually transmitted infections, and husband’s multiple sexual partners were also significantly associated with cervical cancer in the multivariate analysis.ConclusionsOur results could be used to establish a primary prevention program and to prioritize limited screening to women who have specific characteristics that may put them at an increased risk of cervical cancer.

【 授权许可】

CC BY   
© The Author(s). 2017