Antioxidant potential of bitter cumin (Centratherum anthelminticum (L.) Kuntze) seeds in in vitro models

BMC Complementary and Alternative Medicine

Research Article

V Ani¹  Kamatham A Naidu¹ 

[1] Department of Biochemistry and Nutrition, Central Food Technological Research Institute (Council of Scientific and Industrial Research), 570020, Mysore, India;

关键词: Bitter cumin;    Centratherum anthelminticum;    polyphenolic compounds;    antioxidants;    DPPH;    ABTS;    reducing power;    liposomes;    oxidative DNA damage;   

DOI  :  10.1186/1472-6882-11-40

 received in 2010-10-16, accepted in 2011-05-20,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundBitter cumin (Centratherum anthelminticum (L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin. In this study we have further characterized the antioxidative activity of bitter cumin extracts in various in vitro models.MethodsBitter cumin seeds were extracted with a combination of acetone, methanol and water. The antioxidant activity of bitter cumin extracts were characterized in various in vitro model systems such as DPPH radical, ABTS radical scavenging, reducing power, oxidation of liposomes and oxidative damage to DNA.ResultsThe phenolic extracts of bitter cumin at microgram concentration showed significant scavenging of DPPH and ABTS radicals, reduced phosphomolybdenum (Mo(VI) to Mo(V)), ferricyanide Fe(III) to Fe(II), inhibited liposomes oxidation and hydroxyl radical induced damage to prokaryotic genomic DNA. The results showed a direct correlation between phenolic acid content and antioxidant activity.ConclusionBitter cumin is a good source of natural antioxidants.

【 授权许可】

CC BY   
© Ani and Naidu; licensee BioMed Central Ltd. 2011