Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis

BMC Cardiovascular Disorders

Research Article

Hung-Ju Lin¹  Ta-Chen Su¹  Hsiu-Ching Hsu¹  Ming-Fong Chen¹  Yuan-Teh Lee²  Yu-Kang Tu³  Kuo-Liong Chien⁴ 

[1] Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;China Medical University Hospital, Taichung, Taiwan;Division of Biostatistics, Leeds Institute of Genetics, Health & Therapeutics, University of Leeds, Leeds, UK;Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;

关键词: Latent growth curve modeling;    Carotid intima media thickness;    Blood pressure;    LDL cholesterol;   

DOI  :  10.1186/1471-2261-12-66

 received in 2011-10-18, accepted in 2012-08-09,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented.MethodsA total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT.ResultsGreater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047±0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008±0.006, P = 0.20).ConclusionsCarotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation.

【 授权许可】

Unknown   
© Chien et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.