Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis

BMC Cardiovascular Disorders

Yuan-Teh Lee²  Ming-Fong Chen³  Hung-Ju Lin³  Ta-Chen Su³  Hsiu-Ching Hsu³  Yu-Kang Tu¹  Kuo-Liong Chien³ 

[1] Division of Biostatistics, Leeds Institute of Genetics, Health & Therapeutics, University of Leeds, Leeds, UK;China Medical University Hospital, Taichung, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

关键词: LDL cholesterol;    Blood pressure;    Carotid intima media thickness;    Latent growth curve modeling;   

Others  :  1084469
DOI  :  10.1186/1471-2261-12-66

 received in 2011-10-18, accepted in 2012-08-09,  发布年份 2012

【 摘 要 】

Background

The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented.

Methods

A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT.

Results

Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047±0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008±0.006, P = 0.20).

Conclusions

Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation.

【 授权许可】

   
2012 Chien et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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