Association of Platelet to lymphocyte ratio with non-culprit atherosclerotic plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography study

BMC Cardiovascular Disorders

Research Article

Zulong Xie¹  Xinxin Liu²  Jingbo Hou²  Xingtao Huang²  Jiale Lin²  Bo Yu²  Dan Huang²  Xuedong Wang² 

[1] Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China;Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, 150001, Harbin, China;Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, 150001, Harbin, China;

关键词: Platelet to lymphocyte ratio;    Atherosclerosis;    Plaque vulnerability;    Optical coherence tomography;   

DOI  :  10.1186/s12872-017-0618-y

 received in 2017-03-28, accepted in 2017-06-27,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe platelet to lymphocyte ratio (PLR), an indirect inflammatory biomarker, has been recently demonstrated to be associated with severity of coronary artery disease. In the present study, we sought to investigate whether PLR is associated with vulnerable plaque characteristics of non-culprit lesions in patients with acute coronary syndrome (ACS).MethodsThe patients in our study were divided into two groups (high PLR group and low PLR group). A total of 119 non-culprit plaques from 71 patients with ACS were assessed by optical coherence tomography (OCT).ResultsThe non-culprit plaques in high PLR group exhibited thinner fibrous cap thickness (FCT) (88.60 ± 44.70 vs. 119.28 ± 50.22 μm, P = 0.001), greater maximum lipid arc (271.73 ± 71.66 vs. 240.60 ± 76.69°, P = 0.027) and increased incidence of thin-cap fibroatheroma (TCFA) (34.0% vs. 15.9%, P = 0.022) compared with those in low PLR group. Meanwhile, PLR was negatively associated with FCT (r = −0.329, P < 0.001). Furthermore, multivariate regression analysis showed that PLR [OR: 1.023 (95% CI: 1.005–1.041), P = 0.012] and LDL-C [OR: 1.892 (95% CI: 1.106–3.239), P = 0.020] were significant predictors of TCFA.ConclusionsHigh level of PLR may be associated with vulnerable plaque features of non-culprit lesions in patients with ACS. PLR, a cheap and easily available index, may surve as a useful inflammatory marker in reflecting plaque vulnerability.

【 授权许可】

CC BY   
© The Author(s). 2017