Propofol and sufentanil may affect the patients’ sleep quality independently of the surgical stress response: a prospective nonrandomized controlled trial in 1033 patients’ undergone diagnostic upper gastrointestinal endoscopy

BMC Anesthesiology

Research Article

Yunfei Liu¹  Peng Zhang¹  Fangfang Fu¹  Tao Zhu²  Ming Lei³  Ling Ye⁴ 

[1] Department of Anaesthesiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan Province, People’s Republic of China;Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China;Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China;Current address: Department of Anaesthesiology, AVIC 363 Hospital, Chengdu, Sichuan Province, People’s Republic of China;Department of Pain Management, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan Province, People’s Republic of China;

关键词: Propofol;    Anaesthetics;    Sleep;    Pittsburgh Sleep Quality Index;   

DOI  :  10.1186/s12871-017-0341-3

 received in 2016-06-03, accepted in 2017-03-16,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIt is unknown whether sedative per se contributes to the postoperative sleep disturbance. Diagnostic upper gastrointestinal endoscopy (UGE) is a minimally invasive procedure which is not likely to cause tissue trauma and pain. The purpose of this study was to evaluate the sleep quality of patients undergoing routine (without sedative) diagnostic UGE or UGE with sedative, before, 1 week, and 1 month after the procedure.MethodsOne thousand and thirty-three patients undergoing UGE were enrolled. Patients chose sedative or without sedative. Propofol and sufentanil were administered to the sedative group, not allowed for the routine group. The Pittsburgh Sleep Quality Index (PSQI) was measured before, 1 week and 1 month after the procedure.ResultsFive hundred and ten patients were enrolled in the sedative group and 523 in the routine group. One week after the procedure, patients in the sedative group showed significantly higher PSQI scores (worse sleep quality) than the baseline PSQI scores (p < 0.001), but there was no significant change for the routine group in the same period (p = 0.096). One month after the procedure, there was no significant difference in PSQI scores between the two groups compared with the baseline values (p = 0.358 for sedative group, p = 0.161 for routine group). There were also no significant difference in the PSQI scores between the two groups in the entire 1 month follow-up period (p = 0.885).ConclusionsThe sedative group showed impaired sleep quality 1 week after diagnostic UGE. Propofol and sufentanil may independently affect the sleep quality of patients after sedative of diagnostic UGE for only one week.Trial registrationThis study is registered on Chinese Clinical Trial Registry (IDChiCTR-OCH-13003128). Registered 2 April 2013.

【 授权许可】

CC BY   
© The Author(s). 2017