期刊论文详细信息
BMC Anesthesiology
Effect-site concentration of propofol required for LMA-Supreme™ insertion with and without remifentanil: a randomized controlled trial
Maite López-Gil1  Consuelo Jiménez2  Maite Portas2  Salomé Agustí2  Emilia Bastida2  Matilde Zaballos2 
[1]Department of Anaesthesia, Head Department of Anaesthesiology, Hospital Universitario Gregorio Marañón, Madrid, Spain
[2]Department of Anaesthesiology, Hospital Universitario Gregorio Marañón, Madrid, Spain
关键词: Laryngeal mask airway supreme;    Equipment;    Remifentanil;    Propofol;    Intravenous;    Anaesthetics;   
Others  :  1228232
DOI  :  10.1186/s12871-015-0115-8
 received in 2014-12-01, accepted in 2015-09-24,  发布年份 2015
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【 摘 要 】

Background

A new supraglottic device, the LMA-Supreme™, has recently become available for clinical use. Information on anaesthetic and co-adjuvant requirements for insertion of the LMA-Supreme™ is limited. The present study aimed to evaluate the optimal effect-site concentration of propofol in 50 % (EC 50 ) of adults necessary for successful insertion of the LMA-Supreme™ and to examine remifentanil’s effect on propofol requirements.

Methods

Fifty-eight elective patients (aged 18–60 years; ASA (American Society Anaesthesiologists) physical status classification I and II) scheduled for day surgery were randomly assigned to one of two groups: propofol with saline or propofol with remifentanil. Anaesthesia was induced by target-controlled infusion according to predetermined effect-site concentrations of propofol and remifentanil (5 ng.mL −1 ). The EC 50was calculated using Dixon’s up-and-down method. Ten minutes following drug administration, LMA-Supreme™ insertion was attempted without the use of muscle relaxant drugs.

Results

In the propofol + saline group, the EC 50of propofol required for LMA-Supreme™ insertion was 6.32 ± 0.67 μg.mL −1(95 % CI, 5.69–6.94 μg.mL −1 ). With the addition of remifentanil at an effect-site concentration of 5 ng.mL −1 , the EC 50of propofol required for LMA-Supreme™ insertion was 2.50 ± 0.80 μg.mL −1(95 % CI, 1.82–3.17 μg.mL −1 ; p < 0.0001).

Conclusions

The propofol requirement for smooth insertion of the LMA-Supreme™ was 60 % less when remifentanil (5 ng.mL −1 ) was co-administered.

Clinical trial registration

Identified as NCT01974648 at www.clinicaltrials.gov.

【 授权许可】

   
2015 Zaballos et al.

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