A manual-based individual therapy to improve metacognition in schizophrenia: protocol of a multi-center RCT

BMC Psychiatry

Study Protocol

Lex Wunderink¹  Rozanne JM Van Donkersgoed²  André Aleman³  GHM Pijnenborg⁴  Steven De Jong⁴  Mark Van der Gaag⁵  Paul H Lysaker⁶ 

[1] Department of Education and Research, Friesland Mental Health Care Services, PO Box 932, 8901 BS, Leeuwarden, The Netherlands;Department of Psychiatry, University Medical Center Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands;Department of clinical psychology and experimental psychopathology, Faculty of Behavioral and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, 9712, TS Groningen, The Netherlands;Department of Education and Research, Friesland Mental Health Care Services, PO Box 932, 8901 BS, Leeuwarden, The Netherlands;Department of clinical psychology and experimental psychopathology, Faculty of Behavioral and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, 9712, TS Groningen, The Netherlands;Department of Neuroscience, BCN Neuroimaging Center University of Groningen, Medical Center Groningen, Antonius Deusinglaan 2, 9713 AW, Groningen, The Netherlands;Department of clinical psychology and experimental psychopathology, Faculty of Behavioral and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, 9712, TS Groningen, The Netherlands;Department of Psychotic Disorders, GGZ-Drenthe, Dennenweg 9, 9404 LA, Assen, The Netherlands;Parnassia Psychiatric Institute, Prinsegracht 63, 2512 EX, The Hague, The Netherlands;Roudebush VA Medical Center, Indiana School of Medicine, Department of Psychiatry, 1481 West 10th Street, 46292, Indianapolis, IN, USA;

关键词: Schizophrenia;    Psychosis;    Metacognition;    Treatment;    Therapy;    Functioning;   

DOI  :  10.1186/1471-244X-14-27

 received in 2014-01-06, accepted in 2014-01-27,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMetacognitive dysfunction has been widely recognized as a feature of schizophrenia. As it is linked with deficits in several aspects of daily life functioning, improvement of metacognition may lead to improvement in functioning. Individual psychotherapy might be a useful form of treatment to improve metacognition in patients with schizophrenia; multiple case reports and a pilot study show promising results. The present study aims to measure the effectiveness of an individual, manual-based therapy (Metacognitive Reflection and Insight Therapy, MERIT) in improving metacognition in patients with schizophrenia. We also want to examine if improvement in metacognitive abilities is correlated with improvements in aspects of daily life functioning namely social functioning, experience of symptoms, quality of life, depression, work readiness, insight and experience of stigma.Methods/DesignMERIT is currently evaluated in a multicenter randomized controlled trial. Thirteen therapists in six mental health institutions in the Netherlands participate in this study. Patients are randomly assigned to either MERIT or the control condition: treatment as usual (TAU).DiscussionIf proven effective, MERIT can be a useful addition to the care for schizophrenia patients. The design brings along some methodological difficulties, these issues are addressed in the discussion of this paper.Trial registrationCurrent Controlled Trials: ISRCTN16659871.

【 授权许可】

CC BY   
© Van Donkersgoed et al.; licensee BioMed Central Ltd. 2014