A manual-based individual therapy to improve metacognition in schizophrenia: protocol of a multi-center RCT

BMC Psychiatry

GHM Pijnenborg⁶  Lex Wunderink²  Paul H Lysaker¹  André Aleman⁴  Mark Van der Gaag⁵  Steven De Jong⁶  Rozanne JM Van Donkersgoed³ 

[1] Roudebush VA Medical Center, Indiana School of Medicine, Department of Psychiatry, 1481 West 10th Street, Indianapolis, IN 46292, USA;Department of Psychiatry, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands;Department of Education and Research, Friesland Mental Health Care Services, PO Box 932, 8901 BS Leeuwarden, the Netherlands;Department of Neuroscience, BCN Neuroimaging Center, University of Groningen, Medical Center Groningen, Antonius Deusinglaan 2, 9713 AW Groningen, the Netherlands;Parnassia Psychiatric Institute, Prinsegracht 63, 2512 EX The Hague, the Netherlands;Department of Psychotic Disorders, GGZ-Drenthe, Dennenweg 9, 9404 LA Assen, the Netherlands

关键词: Functioning;    Therapy;    Treatment;    Metacognition;    Psychosis;    Schizophrenia;   

Others  :  1123805
DOI  :  10.1186/1471-244X-14-27

 received in 2014-01-06, accepted in 2014-01-27,  发布年份 2014

【 摘 要 】

Background

Metacognitive dysfunction has been widely recognized as a feature of schizophrenia. As it is linked with deficits in several aspects of daily life functioning, improvement of metacognition may lead to improvement in functioning. Individual psychotherapy might be a useful form of treatment to improve metacognition in patients with schizophrenia; multiple case reports and a pilot study show promising results. The present study aims to measure the effectiveness of an individual, manual-based therapy (Metacognitive Reflection and Insight Therapy, MERIT) in improving metacognition in patients with schizophrenia. We also want to examine if improvement in metacognitive abilities is correlated with improvements in aspects of daily life functioning namely social functioning, experience of symptoms, quality of life, depression, work readiness, insight and experience of stigma.

Methods/Design

MERIT is currently evaluated in a multicenter randomized controlled trial. Thirteen therapists in six mental health institutions in the Netherlands participate in this study. Patients are randomly assigned to either MERIT or the control condition: treatment as usual (TAU).

Discussion

If proven effective, MERIT can be a useful addition to the care for schizophrenia patients. The design brings along some methodological difficulties, these issues are addressed in the discussion of this paper.

Trial registration

Current Controlled Trials: ISRCTN16659871.

【 授权许可】

   
2014 Van Donkersgoed et al.; licensee BioMed Central Ltd.

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