Gender differences in the association between adiposity and probable major depression: a cross-sectional study of 140,564 UK Biobank participants

BMC Psychiatry

Research Article

Daniel F Mackay¹  Jason MR Gill¹  Jill P Pell¹  Jonathan Evans¹  Daniel J Smith¹  Daniel Martin¹  Barbara I Nicholl¹  Breda Cullen¹  Zia Ul-Haq²  Matthew Hotopf³  Nick Craddock⁴  John Gallacher⁴  Beverly Roberts⁵  Ian J Deary⁵ 

[1] Institute of Health & Wellbeing, University of Glasgow, 1 Lilybank Gardens, G12 8RZ, Glasgow, UK;Institute of Health & Wellbeing, University of Glasgow, 1 Lilybank Gardens, G12 8RZ, Glasgow, UK;Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan;Kings College London, London, UK;University of Cardiff, Cardiff, UK;University of Edinburgh, Edinburgh, UK;

关键词: Adiposity;    Obesity;    Depression;    Mental health;    Mood disorder;    UK Biobank;   

DOI  :  10.1186/1471-244X-14-153

 received in 2014-01-30, accepted in 2014-05-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPrevious studies on the association between adiposity and mood disorder have produced contradictory results, and few have used measurements other than body mass index (BMI). We examined the association between probable major depression and several measurements of adiposity: BMI, waist circumference (WC), waist-hip-ratio (WHR), and body fat percentage (BF%).MethodsWe conducted a cross-sectional study using baseline data on the sub-group of UK Biobank participants who were assessed for mood disorder. Multivariate logistic regression models were used, adjusting for potential confounders including: demographic and life-style factors, comorbidity and psychotropic medication.ResultsOf the 140,564 eligible participants, evidence of probable major depression was reported by 30,145 (21.5%). The fully adjusted odds ratios (OR) for obese participants were 1.16 (95% confidence interval (CI) 1.12, 1.20) using BMI, 1.15 (95% CI 1.11, 1.19) using WC, 1.09 (95% CI 1.05, 1.13) using WHR and 1.18 (95% CI 1.12, 1.25) using BF% (all p < 0.001). There was a significant interaction between adiposity and gender (p = 0.001). Overweight women were at increased risk of depression with a dose response relationship across the overweight (25.0-29.9 kg/m2), obese I (30.0-34.9 kg/m2), II (35.0-39.9 kg/m2) and III (≥40.0 kg/m2) categories; fully adjusted ORs 1.14, 1.20, 1.29 and 1.48, respectively (all p < 0.001). In contrast, only obese III men had significantly increased risk of depression (OR 1.29, 95% CI 1.08, 1.54, p = 0.006).ConclusionAdiposity was associated with probable major depression, irrespective of the measurement used. The association was stronger in women than men. Physicians managing overweight and obese women should be alert to this increased risk.

【 授权许可】

Unknown   
© Ul-Haq et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.