Gender differences in the association between adiposity and probable major depression: a cross-sectional study of 140,564 UK Biobank participants

BMC Psychiatry

Jill P Pell⁴  Daniel F Mackay⁴  Nick Craddock⁵  Matthew Hotopf¹  John Gallacher⁵  Ian J Deary³  Beverly Roberts³  Jonathan Evans⁴  Jason MR Gill⁴  Daniel Martin⁴  Breda Cullen⁴  Barbara I Nicholl⁴  Daniel J Smith⁴  Zia Ul-Haq² 

[1] Kings College London, London, UK;Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan;University of Edinburgh, Edinburgh, UK;Institute of Health & Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, UK;University of Cardiff, Cardiff, UK

关键词: UK Biobank;    Mood disorder;    Mental health;    Depression;    Obesity;    Adiposity;   

Others  :  1123556
DOI  :  10.1186/1471-244X-14-153

 received in 2014-01-30, accepted in 2014-05-20,  发布年份 2014

【 摘 要 】

Background

Previous studies on the association between adiposity and mood disorder have produced contradictory results, and few have used measurements other than body mass index (BMI). We examined the association between probable major depression and several measurements of adiposity: BMI, waist circumference (WC), waist-hip-ratio (WHR), and body fat percentage (BF%).

Methods

We conducted a cross-sectional study using baseline data on the sub-group of UK Biobank participants who were assessed for mood disorder. Multivariate logistic regression models were used, adjusting for potential confounders including: demographic and life-style factors, comorbidity and psychotropic medication.

Results

Of the 140,564 eligible participants, evidence of probable major depression was reported by 30,145 (21.5%). The fully adjusted odds ratios (OR) for obese participants were 1.16 (95% confidence interval (CI) 1.12, 1.20) using BMI, 1.15 (95% CI 1.11, 1.19) using WC, 1.09 (95% CI 1.05, 1.13) using WHR and 1.18 (95% CI 1.12, 1.25) using BF% (all p < 0.001). There was a significant interaction between adiposity and gender (p = 0.001). Overweight women were at increased risk of depression with a dose response relationship across the overweight (25.0-29.9 kg/m²), obese I (30.0-34.9 kg/m²), II (35.0-39.9 kg/m²) and III (≥40.0 kg/m²) categories; fully adjusted ORs 1.14, 1.20, 1.29 and 1.48, respectively (all p < 0.001). In contrast, only obese III men had significantly increased risk of depression (OR 1.29, 95% CI 1.08, 1.54, p = 0.006).

Conclusion

Adiposity was associated with probable major depression, irrespective of the measurement used. The association was stronger in women than men. Physicians managing overweight and obese women should be alert to this increased risk.

【 授权许可】

   
2014 Ul-Haq et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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