Decision aids for second-line palliative chemotherapy: a randomised phase II multicentre trial

BMC Medical Informatics and Decision Making

Research Article

Linda J. M. Oostendorp¹  A. Rogier T. Donders¹  Peep F. M. Stalmeier¹  Ivonne J. H. Schoenaker²  Agnes J. van de Wouw³  Tineke J. Smilde⁴  Petronella B. Ottevanger⁵  Winette T. A. van der Graaf⁵ 

[1] Department for Health Evidence, Radboudumc, Nijmegen, the Netherlands;Department of Internal Medicine, Isala Clinics, Zwolle, the Netherlands;Department of Internal Medicine, VieCuri Medical Centre, Venlo, the Netherlands;Department of Medical Oncology, Jeroen Bosch Hospital, Den Bosch, the Netherlands;Department of Medical Oncology, Radboudumc, Nijmegen, the Netherlands;

关键词: Breast cancer;    Colorectal cancer;    Oncology;    Decision aids;    Palliative chemotherapy;    Second-line;   

DOI  :  10.1186/s12911-017-0529-y

 received in 2017-01-25, accepted in 2017-08-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThere is increasing recognition of the delicate balance between the modest benefits of palliative chemotherapy and the burden of treatment. Decision aids (DAs) can potentially help patients with advanced cancer with these difficult treatment decisions, but providing detailed information could have an adverse impact on patients' well-being. The objective of this randomised phase II study was to evaluate the safety and efficacy of DAs for patients with advanced cancer considering second-line chemotherapy.MethodsPatients with advanced breast or colorectal cancer considering second-line treatment were randomly assigned to usual care (control group) or usual care plus a DA (intervention group) in a 1:2 ratio. A nurse offered a DA with information on adverse events, tumour response and survival. Outcome measures included patient-reported well-being (primary outcome: anxiety) and quality of the decision-making process and the resulting choice.ResultsOf 128 patients randomised, 45 were assigned to the control group and 83 to the intervention group. Median age was 62 years (range 32-81), 63% were female, and 73% had colorectal cancer. The large majority of patients preferred treatment with chemotherapy (87%) and subsequently commenced treatment with chemotherapy (86%). No adverse impact on patients' well-being was found and nurses reported that consultations in which the DAs were offered went well. Being offered the DA was associated with stronger treatment preferences (3.0 vs. 2.5; p=0.030) and increased subjective knowledge (6.7 vs. 6.3; p=0.022). Objective knowledge, risk perception and perceived involvement were comparable between the groups.ConclusionsDAs containing detailed risk information on second-line palliative treatment could be delivered to patients with advanced cancer without having an adverse impact on patient well-being. Surprisingly, the DAs only marginally improved the quality of the decision-making process. The effectiveness of DAs for palliative treatment decisions needs further exploration.Trial registrationNetherlands Trial Registry (NTR): NTR1113 (registered on 2 November 2007)

【 授权许可】

CC BY   
© The Author(s). 2017