Validation of ethnopharmacological uses of Murraya paniculata in disorders of diarrhea, asthma and hypertension

BMC Complementary and Alternative Medicine

Research Article

Saikat Dewanjee¹  Hawa ZE Jaafar²  Fatima Saqib³  Mobeen Ghulam Ahmed³  Khalid Hussain Janbaz³  Muhammad Zia-Ul-Haq⁴ 

[1] Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, 700032, Kolkata, India;Department of Crop Science, Faculty of Agriculture, University Putra Malaysia, Selangor, Malaysia;Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan;The Patent Office, Karachi, Pakistan;

关键词: Murraya paniculata;    Anti-spasmodic;    Bronchodilator;    Vasodilator;   

DOI  :  10.1186/s12906-015-0837-7

 received in 2015-06-11, accepted in 2015-08-28,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMurraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems.MethodsAqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trachea and aorta) to detect the possible presence of spasmolytic activity. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system.ResultsApplication of the extract of Mp.Cr relaxed spontaneous and high K+ (80mM)-induced contraction in rabbit jejunum preparation. Because it shifted the CRCs (Calcium response curve) towards the right side so the possible blockade was of calcium channel similar to verapamil. In rabbit trachea, extract of Mp.Cr produced relaxation of carbachol and high K+ induced contractions. When plant extract was checked further on isolated aorta for its possible vasodilator effect, it caused relaxation of phenylephrine and high K+-induced spastic contractions at different doses.ConclusionThese results indicate that Murraya paniculata shows anti-spasmodic, bronchodilator and vasodilator activity facilitated through Ca++ antagonist mechanisms.

【 授权许可】

CC BY   
© Saqib et al. 2015