Validation of ethnopharmacological uses of Murraya paniculata in disorders of diarrhea, asthma and hypertension

BMC Complementary and Alternative Medicine

Muhammad Zia-Ul-Haq¹  Hawa ZE Jaafar²  Saikat Dewanjee³  Khalid Hussain Janbaz⁴  Mobeen Ghulam Ahmed⁴  Fatima Saqib⁴ 

[1] The Patent Office, Karachi, Pakistan;Department of Crop Science, Faculty of Agriculture, University Putra Malaysia, Selangor, Malaysia;Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India;Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

关键词: Vasodilator;    Bronchodilator;    Anti-spasmodic;    Murraya paniculata;   

Others  :  1224454
DOI  :  10.1186/s12906-015-0837-7

 received in 2015-06-11, accepted in 2015-08-28,  发布年份 2015

【 摘 要 】

Background

Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems.

Methods

Aqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trachea and aorta) to detect the possible presence of spasmolytic activity. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system.

Results

Application of the extract of Mp.Cr relaxed spontaneous and high K ⁺(80mM)-induced contraction in rabbit jejunum preparation. Because it shifted the CRCs (Calcium response curve) towards the right side so the possible blockade was of calcium channel similar to verapamil. In rabbit trachea, extract of Mp.Cr produced relaxation of carbachol and high K ⁺induced contractions. When plant extract was checked further on isolated aorta for its possible vasodilator effect, it caused relaxation of phenylephrine and high K ⁺ -induced spastic contractions at different doses.

Conclusion

These results indicate that Murraya paniculata shows anti-spasmodic, bronchodilator and vasodilator activity facilitated through Ca ⁺⁺antagonist mechanisms.

【 授权许可】

   
2015 Saqib et al.

【 图 表 】

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