Stability of remission rates in a 3-year follow-up of naturalistic treated depressed inpatients

BMC Psychiatry

Research Article

Mazda Adli¹  Michael Bauer²  Michael Obermeier³  Hans-Jürgen Möller³  Rebecca Schennach³  Peter Falkai³  Michael Riedel⁴  Florian Seemüller⁵  Peter Brieger⁶  Gerd Laux⁷ 

[1] Department of Psychiatry and Psychotherapy, Campus, Charité Mitte (CCM), Charitéplatz 1, 10117, Berlin, Germany;Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Dresden, Technical University Dresden, Fetscherstr. 74, 01307, Dresden, Germany;Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany;Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany;Department of Psychiatry and Psychotherapy, Vinzenz von Paul Hospital, Rottweil, Germany;Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany;Department of Psychiatry, Psychosomatic and Psychotherapy, kbo-Lech-Mangfall-Klinik, Garmisch-Patenkirchen, Germany;Department of Psychiatry and Psychotherapy, Martin-Luther University Halle-Wittenberg, Julius-Kühn-Str.7, 06097, Halle, Germany;Department of Psychiatry, Psychosomatic and Psychotherapy, Bezirkskrankenhaus Kempten, Robert-Weixlerstrasse 46, 87435, Kempten, Germany;Department of Psychiatry and Psychotherapy, kbo-Inn-Salzach-Klinikum, Gabersee 7, 83512, Wasserburg, Germany;

关键词: Major Depressive Disorder;    Remission Rate;    Inpatient Treatment;    Major Depressive Episode;    Last Observation Carry Forward;   

DOI  :  10.1186/s12888-016-0851-4

 received in 2016-02-23, accepted in 2016-05-05,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundRemission is a common outcome of short-term trials and the main goal of acute and longterm treatment. The longitudinal stability of remission has rarely been investigated under naturalistic treatment conditions.MethodsNaturalistic multisite follow-up study. Three-year symptomatic long-term outcome of initially hospitalized tertiary care patients (N = 784) with major depressive episodes. Remission rates as well as the switch rates between remission and non-remission were reported.ResultsAfter one, two and three years 62 %, 59 % and 69 % of the observed patients met criteria for remission. During the follow-up 88 % of all patients achieved remission. 36 % of maintained remission from discharge to 3-years, 12 % of all patients never reached remission and 52 % percent showed a fluctuating course switching from remission to non-remission and vice versa. There was considerable transition between remission and non-remission. For example, from discharge to 1 year, from 1 to 2, and from 2 to 3 years 25 %, 21 % and 11 % lost remission.ConclusionCumulative outcome rates are encouraging. Absolute rates at predefined endpoints as well as the fluctuations between these outcomes reflect the variable and chronic nature of major depression.

【 授权许可】

CC BY   
© Seemüller et al. 2016