Criteria for symptom remission revisited: a study of patients affected by schizophrenia and schizoaffective disorders

BMC Psychiatry

Research Article

Roberto Cavallaro¹  Marta Bosia²  Federica Pinna³  Bernardo Carpiniello³  Massimo Tusconi³ 

[1] Department of Clinical Neurosciences, San Raffaele Scientific Institute, Via Stamira d’Ancona 20, 20127, Milan, Italy;Department of Clinical Neurosciences, San Raffaele Scientific Institute, Via Stamira d’Ancona 20, 20127, Milan, Italy;Institute for Advanced Study, IUSS, Center for Neurolinguistics and Theoretical Syntax (NeTS), Pavia, Italy;Department of Public Health, Clinical and Molecular Medicine-Section of Psychiatry, University of Cagliari, Via Liguria 13, 09127, Cagliari, Italy;

关键词: Remission Rate;    Clinical Remission;    Cognitive Outcome;    Schizoaffective Disorder;    General Linear Model Analysis;   

DOI  :  10.1186/1471-244X-13-235

 received in 2013-05-22, accepted in 2013-09-24,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThis study aims to compare severity criteria defined by the Remission in Schizophrenia Working Group (RSWGcr) with other criteria in relation to functional and neurocognitive outcome.Methods112 chronic psychotic outpatients were examined. Symptomatic remission according to RSWGcr was compared with the outcome achieved using criteria based on PANSS Positive and Negative Scales (PANSS-PNScr) and the entire PANSS (PANNS-TScr).ResultsRemission rates were 50%, 35% and 23% respectively at RSWGcr, PANSS-PNScr and PANNS-TScr; functional remission rates were 32%, 42% and 54%. Sensitivity, specificity, predictive value and ROC analysis demonstrated the superiority of PANSS-PNScr in identifying patients with higher functional and cognitive outcomes. Regression analysis showed a significant predictive effect of PANSS-TScr on functioning. General linear model analyses demonstrated significantly higher mean scores at PSP and BACS for patients remitted according to PANSS-TScr.ConclusionThe use of more restrictive severity criteria of remission seems to be associated with improved identification of truly remitted patients.

【 授权许可】

Unknown   
© pinna et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.